caa a22 4500 465738567 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02244134 doi (NATIONALLICENCE)springer-10.1007/BF02244134 Chronic administration of the 5-HT3 receptor antagonist BRL 43694; effects on reflex epilepsy and social behaviour of the Mongolian gerbil [Elektronische Daten] [Margaret Cutler, David Piper] The 5-HT3 receptor antagonist BRL 43694 was administered in drinking fluid to Mongolian gerbils, previously selected for their propensity to exhibit seizures on mild stimulation, for 11 days at doses of 1.5 µg/kg, 150 µg/kg and 1 mg/kg daily, while controls received tap water. Effects upon behaviour during encounters under white light with an untreated resident gerbil were assessed using ethological procedures. Effects upon seizure susceptibility and severity were also examined. All doses of BRL 43694 significantly increased the time spent by gerbils in the social activity "attend”, and acts of social investigation involving physical contact between animals were significantly increased only by the highest dose of 1 mg/kg, as was occurrence of the specific element, "groom”. The duration of flight was increased in gerbils receiving the drugs at 1.5 µg/kg. The treatment had no effect upon seizure susceptibility or severity. It is suggested that BRL 43694 increases the sensitivity of gerbils to their social environment. At the lower dose this was seen as an increase in flight, at all doses it was associated with increase of the social activity "attend” and at the high dose it was manifested as an increase in active social interaction. Further investigations are required to assess the relevance of these findings to the purported anxiolytic activity of 5-HT3 receptor antagonists. Springer-Verlag, 1990 5-HT3 receptor antagonist nationallicence BRL 43694 nationallicence Gerbil nationallicence Social interaction nationallicence Seizure susceptibility nationallicence Cutler Margaret Department of Biological Sciences, Glasgow College, Cowcaddens Road, G4 OBA, Glasgow, UK aut Piper David Beecham Pharmaceuticals, Coldharbour Road, The Pinnacles, CM19 5AD, Harlow, Essex, UK aut Psychopharmacology Springer-Verlag 101/2(1990-06-01), 244-249 0033-3158 101:2<244 1990 101 213 https://doi.org/10.1007/BF02244134 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244134 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cutler Margaret Department of Biological Sciences, Glasgow College, Cowcaddens Road, G4 OBA, Glasgow, UK aut NATIONALLICENCE 700 1- Piper David Beecham Pharmaceuticals, Coldharbour Road, The Pinnacles, CM19 5AD, Harlow, Essex, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/2(1990-06-01), 244-249 0033-3158 101:2<244 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer