caa a22 4500 465738575 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900601xx s 000 0 eng 10.1007/BF02244125 doi (NATIONALLICENCE)springer-10.1007/BF02244125 Dews P. Laboratory of Psychobiology, Department of Psychiatry, Harvard Medical School, 02115, Boston, MA, USA aut Directional running in mice: effects of cocaine and chlorpromazine [Elektronische Daten] [P. Dews] Mice ran in a circular runway. Some received milk at every third circuit in a designated direction, clockwise or counterclockwise, in daily 1000-s sessions. Under control conditions, about 10 times as many circuits were made in the reinforced direction as in the non-reinforced direction. Cocaine (10, 30, 100 µM/kg) had little effect on the total number of circuits, but progressively increased the number in the non-reinforced direction. Chlorpromazine (1, 3, 10, 30 µM/kg) caused a monotonic decrease in total number of circuits and in number in non-reinforced direction. At the highest doses the proportion in the non-reinforced direction was increased. Mice, untrained in the runway and with no reinforcement of circuits in either direction, made many fewer total circuits than when running was reinforced and about equal numbers were in clockwise and in counterclockwise directions. Cocaine greatly increased the total number of circuits. As in the subjects whose running was reinforced, cocaine led to a much higher tendency for mice to run in a single direction. The similarities between the tendency to run in one direction after cocaine and the rotational behavior of rodents seen after cocaine and amphetamine suggest a common mechanism. Springer-Verlag, 1990 Cocaine nationallicence Chlorpromazine nationallicence Mice nationallicence Directional running nationallicence Drug-induced rotation nationallicence Schedule-controlled running nationallicence Psychopharmacology Springer-Verlag 101/2(1990-06-01), 190-195 0033-3158 101:2<190 1990 101 213 https://doi.org/10.1007/BF02244125 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244125 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Dews P. Laboratory of Psychobiology, Department of Psychiatry, Harvard Medical School, 02115, Boston, MA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 101/2(1990-06-01), 190-195 0033-3158 101:2<190 1990 101 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer