caa a22 4500 46573863X CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02245791 doi (NATIONALLICENCE)springer-10.1007/BF02245791 Regional neurotransmitter responses after acute and chronic electroconvulsive shock [Elektronische Daten] [Paul Glue, Michael Gostello, Agu Pert, Andrea Mele, David Nutt] Regional neurotransmitter changes after acute and chronic electroconvulsive shock (ECS) were studied using the technique of repeated microdialysis. Microdialysis was carried out on alternate sides of the brains of anaesthetised rats before and during the first and the eighth ECS or sham (control) treatments. Extracellular fluid release of monoamines and their metabolites was measured in the frontal cortex, striatum and nucleus accumbens using HPLC with electrochemical detection. The first ECS produced selective regional responses, shown by increased concentrations of noradrenaline (NA) and dopamine (DA) in frontal cortex, by unchanged DA content in striatum, and by a small rise in NA and a fall in DA concentrations in nucleus accumbens. Concentrations of metabolites increased after ECS in all regions studied, and for homovanillic acid and dihydroxyphenylacetic acid, the temporal pattern of these changes did not resemble that of DA. Comparison of neurotransmitter responses as per cent of baseline release after the first and eighth ECS treatments showed they were identical. Basal release of monoamines and metabolites before the first ECS or sham treatment was similar in all regions studied. Prior to the eighth treatment, basal release of NA in the frontal cortex and DA in the striatum was elevated in the ECS-treated animals, while basal release of NA in the nucleus accumbens was reduced in both ECS-and sham-treated animals. These data suggest that acute and chronic ECS have different and region-specific effects on neurotransmitter release, although the overall pattern of these responses is not changed by chronic treatment. The catecholamine-releasing actions of ECS, and the changes in basal release of neurotransmitters seen after chronic treatment may contribute to its therapeutic effects. Springer-Verlag, 1990 Microdialysis nationallicence Electroconvulsive shock nationallicence Noradrenaline nationallicence Dopamine nationallicence Regional responses nationallicence Rat nationallicence Glue Paul National Institute on Alcohol Abuse and Alcoholism, USA aut Gostello Michael National Institute on Alcohol Abuse and Alcoholism, USA aut Pert Agu National Institute of Mental Health, 20892, Bethesda, MD, USA aut Mele Andrea National Institute of Mental Health, 20892, Bethesda, MD, USA aut Nutt David National Institute on Alcohol Abuse and Alcoholism, USA aut Psychopharmacology Springer-Verlag 100/1(1990-03-01), 60-65 0033-3158 100:1<60 1990 100 213 https://doi.org/10.1007/BF02245791 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245791 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Glue Paul National Institute on Alcohol Abuse and Alcoholism, USA aut NATIONALLICENCE 700 1- Gostello Michael National Institute on Alcohol Abuse and Alcoholism, USA aut NATIONALLICENCE 700 1- Pert Agu National Institute of Mental Health, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Mele Andrea National Institute of Mental Health, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Nutt David National Institute on Alcohol Abuse and Alcoholism, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/1(1990-03-01), 60-65 0033-3158 100:1<60 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer