caa a22 4500 465738648 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02245788 doi (NATIONALLICENCE)springer-10.1007/BF02245788 Biliary excretion of reduced haloperidol glucuronide [Elektronische Daten] [Natalie Eddington, David Young] The biliary excretion of haloperidol and reduced haloperidol were investigated in the guinea pig. Bile duct cannulated guinea pigs were administered a single intraperitoneal dose of haloperidol (1 mg/kg). Bile was continually collected over a 12-h period. Aliquots of the bile samples were analyzed by HPLC for free haloperidol and reduced haloperidol. The remaining portions of the bile samples were incubated with beta glucuronidase and reanalyzed for haloperidol and reduced haloperidol. Although no significant amount of haloperidol glucuronide was detected in the bile, a new metabolite of reduced haloperidol, reduced haloperidol glucuronide, was found. The amount of reduced haloperidol excreted in the bile as the glucuronide conjugate was significantly higher than the amount of haloperidol or reduced haloperidol. These results imply that reduced haloperidol glucuronide may play a role in the disposition of haloperidol and/or its metabolite, reduced haloperidol. Springer-Verlag, 1990 Haloperidol nationallicence Reduced haloperidol nationallicence Biliary excretion nationallicence Glucuronide conjugates nationallicence Eddington Natalie Clinical Pharmacokinetics Laboratory, Department of Pharmaceutics, School of Pharmacy, 20 North Pine Street, 21201, Baltimore, MD, USA aut Young David Clinical Pharmacokinetics Laboratory, Department of Pharmaceutics, School of Pharmacy, 20 North Pine Street, 21201, Baltimore, MD, USA aut Psychopharmacology Springer-Verlag 100/1(1990-03-01), 46-48 0033-3158 100:1<46 1990 100 213 https://doi.org/10.1007/BF02245788 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245788 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Eddington Natalie Clinical Pharmacokinetics Laboratory, Department of Pharmaceutics, School of Pharmacy, 20 North Pine Street, 21201, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Young David Clinical Pharmacokinetics Laboratory, Department of Pharmaceutics, School of Pharmacy, 20 North Pine Street, 21201, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/1(1990-03-01), 46-48 0033-3158 100:1<46 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer