caa a22 4500 465738664 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02245801 doi (NATIONALLICENCE)springer-10.1007/BF02245801 Idazoxan increases rough-and-tumble play, activity and exploration in juvenile rats [Elektronische Daten] [Stephen Siviy, Dale Atrens, Jose Menendez] The effects of idazoxan, an alpha-2 noradrenergic antagonist, on play and open field behavior were assessed in juvenile rats. Play was assessed in two separate paradigms. Initially, juvenile rats were housed individually and given a daily 5 min opportunity to play with a responsive partner. Idazoxan (1-8 mg/kg) increased pinning, an indicator variable of play, but did not affect the frequency of dorsal contacts, an index of play solicitation. When rats were tested in a separate test for play solicitation using an unresponsive play partner, idazoxan increased all three measures of play solicitation. Idazoxan increased activity and exploration when rats were tested in an open field, suggesting that the effects of idazoxan on play may be due to an increase in behavioral arousal and/or attention. These data are consistent with a modulatory role for norepinephrine in the control of behavior. Springer-Verlag, 1990 Idazoxan nationallicence Norepinephrine nationallicence Play nationallicence Alpha-2 adrenoceptors nationallicence Activity nationallicence Exploration nationallicence Siviy Stephen Department of Psychology, University of Sydney, 2006, Sydney, NSW, Australia aut Atrens Dale Department of Psychology, University of Sydney, 2006, Sydney, NSW, Australia aut Menendez Jose Department of Psychology, University of Sydney, 2006, Sydney, NSW, Australia aut Psychopharmacology Springer-Verlag 100/1(1990-03-01), 119-123 0033-3158 100:1<119 1990 100 213 https://doi.org/10.1007/BF02245801 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245801 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Siviy Stephen Department of Psychology, University of Sydney, 2006, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Atrens Dale Department of Psychology, University of Sydney, 2006, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Menendez Jose Department of Psychology, University of Sydney, 2006, Sydney, NSW, Australia aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/1(1990-03-01), 119-123 0033-3158 100:1<119 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer