caa a22 4500 465738672 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02245799 doi (NATIONALLICENCE)springer-10.1007/BF02245799 Repeated ECS enhances dopamine D-1 but not D-2 agonist-induced behavioural responses in rats [Elektronische Daten] [T. Sharp, J. Kingston, D. Grahame-Smith] The present study examined the effect of acute and repeated administration of electroconvulsive shock (ECS) on behaviours induced by various dopamine agonists in rats. Components of behavioural arousal induced by the dopamine D-1 agonist SKF 38393, the dopamine D-2 agonist RU 24213 and the mixed D-1/D-2 agonist apomorphine were assessed using a behavioural check-list method. Also, the overall behavioural syndrome produced by these drugs was measured using rating scales. Rats receiving repeated (5 times over 10 days) but not a single ECS showed enhanced grooming and sniffing in response to SKF 38393 (7.5 mg/kg) when compared to controls. Repetitive sniffing induced by apomorphine (0.5 mg/kg) was also enhanced by repeated ECS. Neither repeated nor a single ECS significantly changed behaviours induced by RU 24213 (0.75 mg/kg), although a downward trend was evident. The behaviour rating scale measurements also demonstrated that repeated administration to ECS increased behavioural responsiveness to SKF 38393 and apomorphine but not RU 24213. These results suggest that the increase of dopamine-mediated behaviour in rats seen after chronic ECS relates to an increase in central dopamine D-1 receptor function. Springer-Verlag, 1990 Electroconvulsive shock nationallicence Dopamine receptor subtypes nationallicence SKF 38393 nationallicence RU 24213 nationallicence Apomorphine nationallicence Sharp T. MRC Unit and University Department of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road, OX26HE, Oxford, UK aut Kingston J. MRC Unit and University Department of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road, OX26HE, Oxford, UK aut Grahame-Smith D. MRC Unit and University Department of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road, OX26HE, Oxford, UK aut Psychopharmacology Springer-Verlag 100/1(1990-03-01), 110-114 0033-3158 100:1<110 1990 100 213 https://doi.org/10.1007/BF02245799 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245799 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sharp T. MRC Unit and University Department of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road, OX26HE, Oxford, UK aut NATIONALLICENCE 700 1- Kingston J. MRC Unit and University Department of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road, OX26HE, Oxford, UK aut NATIONALLICENCE 700 1- Grahame-Smith D. MRC Unit and University Department of Clinical Pharmacology, Radcliffe Infirmary, Woodstock Road, OX26HE, Oxford, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/1(1990-03-01), 110-114 0033-3158 100:1<110 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer