caa a22 4500 465738680 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02245781 doi (NATIONALLICENCE)springer-10.1007/BF02245781 Lithium and serotonin function: implications for the serotonin hypothesis of depression [Elektronische Daten] [Lawrence Price, Dennis Charney, Pedro Delgado, George Heninger] Lithium enjoys wide clinical use in the treatment of affective disorders, but the mechanism of its action in these conditions is still controversial. Recent studies have shown that lithium can interact with other antidepressant drugs to enhance their efficacy, perhaps by specific effects on serotonin (5-HT) function. A large body of independent evidence suggests that 5-HT function is abnormal in depression. This review documents preclinical evidence of lithium's effects on 5-HT function at the levels of precursor uptake, synthesis, storage, catabolism, release, receptors, and receptor-effector interactions. The weight of this evidence suggests that lithium's primary actions on 5-HT may be presynaptic, with many secondary postsynaptic effects. Studies in humans, using very different methodological approaches, generally suggest that lithium has a net enhancing effect on 5-HT function. These actions of lithium may serve to correct as-yet unspeccified abnormalities of 5-HT function involved in the pathogenesis of depression. Springer-Verlag, 1990 Lithium nationallicence Serotonin nationallicence Depression nationallicence Price Lawrence Clinical Neuroscience Research Unit, Ribicoff Research Facilities, Connecticut Mental Health Center, USA aut Charney Dennis Clinical Neuroscience Research Unit, Ribicoff Research Facilities, Connecticut Mental Health Center, USA aut Delgado Pedro Clinical Neuroscience Research Unit, Ribicoff Research Facilities, Connecticut Mental Health Center, USA aut Heninger George Clinical Neuroscience Research Unit, Ribicoff Research Facilities, Connecticut Mental Health Center, USA aut Psychopharmacology Springer-Verlag 100/1(1990-03-01), 3-12 0033-3158 100:1<3 1990 100 213 https://doi.org/10.1007/BF02245781 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245781 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Price Lawrence Clinical Neuroscience Research Unit, Ribicoff Research Facilities, Connecticut Mental Health Center, USA aut NATIONALLICENCE 700 1- Charney Dennis Clinical Neuroscience Research Unit, Ribicoff Research Facilities, Connecticut Mental Health Center, USA aut NATIONALLICENCE 700 1- Delgado Pedro Clinical Neuroscience Research Unit, Ribicoff Research Facilities, Connecticut Mental Health Center, USA aut NATIONALLICENCE 700 1- Heninger George Clinical Neuroscience Research Unit, Ribicoff Research Facilities, Connecticut Mental Health Center, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/1(1990-03-01), 3-12 0033-3158 100:1<3 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer