caa a22 4500 465738699 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02245787 doi (NATIONALLICENCE)springer-10.1007/BF02245787 Evaluation and comparison of the interaction between alcohol and moclobemide or clomipramine in healthy subjects [Elektronische Daten] [Ivan Berlin, Antoine Cournot, Robert Zimmer, Anne-Marie Pedarriosse, Robert Manfredi, Patricia Molinier, Alain Puech] The interaction of clomipramine and moclobemide with alcohol was compared in a double blind parallel groups study in 24 healthy volunteers. Moclobemide was given at the highest recommended therapeutic dose (200 mg t.i.d.) and clomipramine in a subtherapeutic dose (25 mg b.i.d.) because of its poor tolerance in healthy subjects. Psychometric evaluations were performed during a placebo run-in phase; after a 5-day treatment period; assessments were made before, and again 1 h and 4 h after alcohol ingestion. Alcohol doses were pre-determined for each subject in order to produce a blood alcohol concentration of 0.6 g/l 1 h after alcohol intake and this individual alcohol dose was given on test days. The day before alcohol intake tests for autonomic functions were made to assess the anticholinergic effects of the drugs. Alcohol significantly increased body sway, decreased critical flicker fusion frequency, prolonged choice reaction time, impaired copying skills, impaired memory and increased the subjective feelings of satisfaction and tension. Drugs increased the effect of alcohol on body sway and this was essentially due to clomipramine. Clomipramine both without and with alcohol increased body sway, prolonged choice reaction time more than did moclobemide. Clomipramine seemed to diminish alcohol-induced memory impairment in one of the memory tests used. Subjects taking clomipramine had significantly more adverse effects after alcohol ingestion than did subjects of the moclobemide group. In contrast to moclobemide, clomipramine produced a moderate but significant drop in standing systolic blood pressure and a clear inhibition of salivary excretion. It may be concluded that no important psychometric differences occurred between moclobemide and clomipramine with respect to their interaction with alcohol but moclobemide did not show anticholinergic properties and produced fewer adverse effects than clomipramine in interaction with alcohol. Springer-Verlag, 1990 Clomipramine nationallicence Moclobemide nationallicence Interaction with alcohol nationallicence Psychometric performance nationallicence Body sway nationallicence Anticholinergic effects nationallicence Berlin Ivan Département de Pharmacologie Clinique, Hôpital Pitié-Salpêtrière, 47, Bd de l'Hôpital, F-75013, Paris, France aut Cournot Antoine Therapharm Recherches, 59, rue de Billancourt, F-92100, Boulogne, France aut Zimmer Robert Hoffmann-La Roche Ltd, CH-4002, Basle, Switzerland aut Pedarriosse Anne-Marie Produits Roche, 52, boulevard du Parc, F-92521, Neuilly-sur-Seine, France aut Manfredi Robert Produits Roche, 52, boulevard du Parc, F-92521, Neuilly-sur-Seine, France aut Molinier Patricia Therapharm Recherches, 59, rue de Billancourt, F-92100, Boulogne, France aut Puech Alain Département de Pharmacologie Clinique, Hôpital Pitié-Salpêtrière, 47, Bd de l'Hôpital, F-75013, Paris, France aut Psychopharmacology Springer-Verlag 100/1(1990-03-01), 40-45 0033-3158 100:1<40 1990 100 213 https://doi.org/10.1007/BF02245787 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245787 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berlin Ivan Département de Pharmacologie Clinique, Hôpital Pitié-Salpêtrière, 47, Bd de l'Hôpital, F-75013, Paris, France aut NATIONALLICENCE 700 1- Cournot Antoine Therapharm Recherches, 59, rue de Billancourt, F-92100, Boulogne, France aut NATIONALLICENCE 700 1- Zimmer Robert Hoffmann-La Roche Ltd, CH-4002, Basle, Switzerland aut NATIONALLICENCE 700 1- Pedarriosse Anne-Marie Produits Roche, 52, boulevard du Parc, F-92521, Neuilly-sur-Seine, France aut NATIONALLICENCE 700 1- Manfredi Robert Produits Roche, 52, boulevard du Parc, F-92521, Neuilly-sur-Seine, France aut NATIONALLICENCE 700 1- Molinier Patricia Therapharm Recherches, 59, rue de Billancourt, F-92100, Boulogne, France aut NATIONALLICENCE 700 1- Puech Alain Département de Pharmacologie Clinique, Hôpital Pitié-Salpêtrière, 47, Bd de l'Hôpital, F-75013, Paris, France aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/1(1990-03-01), 40-45 0033-3158 100:1<40 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer