caa a22 4500 465738702 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02245796 doi (NATIONALLICENCE)springer-10.1007/BF02245796 Age-related increase in CNS sensitivity to benzodiazepines as assessed by task difficulty [Elektronische Daten] [Arlene Nikaido, Everett Ellinwood Jr., Douglas Heatherly, Samir Gupta] The differential sensitivity of young and elderly healthy adults to the impairment effects of benzodiazepines was assessed by tasks with several levels of difficulty. Using a double-blind procedure, single doses of placebo, alprazolam (0.75 and 1.5 mg) and triazolam (0.25 and 0.5 mg) were ingested orally by 10 young men, 9 young women, 7 elderly men, and 10 elderly women. Order of drug administration was determined by a random Latin square design. Different versions of the subcritical tracking and digit symbol substitution tasks were characterized by three difficulty levels. Assessments of task performance were conducted at varying intervals for 7 h after drug administration. Both drugs induced a rapid initial onset of impairment in the two age groups. Evidence of increased drug sensitivity in the elderly was provided by the more prolonged duration of the pharmacologic effect in the older than young subjects, especially for the harder versions of the SCT and DSS tasks. In summary, the data provide support for the hypothesis of an age-related decline in the adaptive capacity to inhibit adverse drug effects. Springer-Verlag, 1990 Alprazolam nationallicence Triazolam nationallicence Age differences nationallicence Task difficulty nationallicence Nikaido Arlene Behavioral Neuropharmacology Laboratory, Department of Psychiatry, Duke University Medical Center, Box 3870, 27710, Durham, NC, USA aut Ellinwood Jr. Everett Behavioral Neuropharmacology Laboratory, Department of Psychiatry, Duke University Medical Center, Box 3870, 27710, Durham, NC, USA aut Heatherly Douglas Behavioral Neuropharmacology Laboratory, Department of Psychiatry, Duke University Medical Center, Box 3870, 27710, Durham, NC, USA aut Gupta Samir Behavioral Neuropharmacology Laboratory, Department of Psychiatry, Duke University Medical Center, Box 3870, 27710, Durham, NC, USA aut Psychopharmacology Springer-Verlag 100/1(1990-03-01), 90-97 0033-3158 100:1<90 1990 100 213 https://doi.org/10.1007/BF02245796 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245796 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nikaido Arlene Behavioral Neuropharmacology Laboratory, Department of Psychiatry, Duke University Medical Center, Box 3870, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Ellinwood Jr Everett Behavioral Neuropharmacology Laboratory, Department of Psychiatry, Duke University Medical Center, Box 3870, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Heatherly Douglas Behavioral Neuropharmacology Laboratory, Department of Psychiatry, Duke University Medical Center, Box 3870, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Gupta Samir Behavioral Neuropharmacology Laboratory, Department of Psychiatry, Duke University Medical Center, Box 3870, 27710, Durham, NC, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/1(1990-03-01), 90-97 0033-3158 100:1<90 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer