caa a22 4500 465738737 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02245804 doi (NATIONALLICENCE)springer-10.1007/BF02245804 Bergman Jack Department of Psychiatry, Harvard Medical School and New England Regional Primate Research Center, One Pine Hill Drive, 01772, Southborough, MA, USA aut Psychomotor stimulant effects of the stereoisomers of chlorpheniramine [Elektronische Daten] [Jack Bergman] The behavioral effects of the histamine H1 antagonistsd- andl-chlorpheniramine and of the H2 antagonist zolantidine were determined in squirrel monkeys responding under a fixed-interval (FI) 3-min schedule of stimulus-shock termination. Althoughd-chlorpheniramine is known to be much more potent thanl-chlorpheniramine for antagonizing H1 receptor-mediated effects of histamine or displacing [3H]-mepyramine from histamine H1 receptors, similar doses of racemic chlorpheniramine and thed- andl-isomers (3.0-10.0 mg/kg) produced comparable increases in rates of responding. Zolantidine (1.0-17.0 mg/kg) did not alter or, at the highest dose, markedly decreased responding. These findings suggest that the psychomotor stimulant effects of chlorpheniramine involve actions other than the blockade of histamine H1 or H2 receptors. Selected H1 antagonists and cocaine are known to have comparable rateincreasing, reinforcing, and discriminative stimulus effects and, recently, the enantiomers of chlorpheniramine have been shown to displace [3H]-cocaine from binding sites in CNS with approximately equal potency. Possibly, such actions mediate behavioral effects common to H1 antagonists and cocaine. Springer-Verlag, 1990 Chlorpheniramine nationallicence d -Chlorpheniramine nationallicence l -Chlorpheniramine nationallicence H1 antagonists nationallicence Psychomotor stimulants nationallicence Schedule-controlled behavior nationallicence Psychopharmacology Springer-Verlag 100/1(1990-03-01), 132-134 0033-3158 100:1<132 1990 100 213 https://doi.org/10.1007/BF02245804 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245804 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Bergman Jack Department of Psychiatry, Harvard Medical School and New England Regional Primate Research Center, One Pine Hill Drive, 01772, Southborough, MA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/1(1990-03-01), 132-134 0033-3158 100:1<132 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer