caa a22 4500 465738745 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02245793 doi (NATIONALLICENCE)springer-10.1007/BF02245793 Johansson Per Psychiatric Research Center, University of Uppsala, S-750 17, Uppsala, Sweden aut Methylazoxymethanol (MAM)-induced brain lesion and oral dyskinesia in rats [Elektronische Daten] [Per Johansson] The effects of methylazoxymethanol (MAM)-induced brain lesions on vacuous chewing movements (VCM) were examined in rats given chronic haloperidol treatment (0.1 or 1 mg/kg/day) for 18 months. At the end of the experiment striatal, pallidal, and nigral activities of glutamate decarboxylase (GAD) were measured. MAM-lesioned rats had an elevated rate of VCMs compared to unlesioned controls. This effect was stable during the whole 18-month experiment. In unlesioned control rats chronic haloperidol produced a gradual increase in VCM rates, but this effect was not further exacerbated in MAM-lesioned animals. After chronic haloperidol treatment with the higher dose (1 mg/kg/day) GAD activity was reduced in substantia nigra (-20%), globus pallidus (-35%), and striatum (-26%) of unlesioned rats. MAM caused a reduction of GAD activity in substantia nigra (-29%) and globus pallidus (-29%). Chronic haloperidol did not influence these effects of MAM-induced lesion. The present results show that a MAM-induced brain lesion, in contrast to cortical ablations, cannot be used to amplify the haloperidol-induced VCM increase or influence the nigral GAD activity in a rat model for tardive dyskinesia. Springer-Verlag, 1990 Methylazoxymethanol (MAM) nationallicence Haloperidol nationallicence Vacuous chewing movements (VCM) nationallicence Glutamate decarboxylase (GAD) nationallicence Tardive dyskinesia nationallicence Rat nationallicence Psychopharmacology Springer-Verlag 100/1(1990-03-01), 72-76 0033-3158 100:1<72 1990 100 213 https://doi.org/10.1007/BF02245793 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245793 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Johansson Per Psychiatric Research Center, University of Uppsala, S-750 17, Uppsala, Sweden aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/1(1990-03-01), 72-76 0033-3158 100:1<72 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer