caa a22 4500 465738788 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02245795 doi (NATIONALLICENCE)springer-10.1007/BF02245795 TRH attenuates scopolamine-induced memory impairment in humans [Elektronische Daten] [Susan Molchan, Alan Mellow, Brian Lawlor, Herbert Weingartner, Robert Cohen, Martin Cohen, Trey Sunderland] The brain tripeptide thyrotropin-releasing hormone (TRH) has been demonstrated to facilitate cholinergic neurotransmission. To test its interaction with the cholinergic system in humans, high-dose TRH (0.5 mg/kg) or placebo was administered intravenously (IV) to normal controls pretreated with scopolamine (0.5-0.75 mg IV), a centrally active muscarinic antagonist, which has been used to model aspects of the memory impairment of normal aging and of dementia. Compared to placebo, TRH markedly attenuated scopolamine-induced impairment of some measures of memory, most notably on a selective reminding task. This cognitive study is the first in humans to suggest a neuromodulatory effect of a peptide on the cholinergic system, and suggests a facilitatory role for TRH in human memory processes. Springer-Verlag, 1990 Thyrotropin-releasing hormone (TRH) nationallicence Neuropeptide nationallicence Scopolamine nationallicence Memory nationallicence Molchan Susan Unit on Geriatric Psychopharmacology, Section on Clinical Neuropharmacology, Laboratory of Clinical Science, National Institute of Mental Health, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut Mellow Alan Department of Psychiatry, University of Michigan Medical Center, 1103 East Huron, 48104, Ann Arbor, MI, USA aut Lawlor Brian Unit on Geriatric Psychopharmacology, Section on Clinical Neuropharmacology, Laboratory of Clinical Science, National Institute of Mental Health, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut Weingartner Herbert Department of Psychology, George Washington University, 2125 G Street, N.W., 20036, Washington, DC, USA aut Cohen Robert Section on Clinical Brain Imaging, Laboratory of Cerebral Metabolism, National Institute of Mental Health, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut Cohen Martin Ensor Research Laboratory, William S. Hall Psychiatric Institute, University of South Carolina School of Medicine, P.O. Box 202, 29202, Columbia, SC, USA aut Sunderland Trey Unit on Geriatric Psychopharmacology, Section on Clinical Neuropharmacology, Laboratory of Clinical Science, National Institute of Mental Health, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut Psychopharmacology Springer-Verlag 100/1(1990-03-01), 84-89 0033-3158 100:1<84 1990 100 213 https://doi.org/10.1007/BF02245795 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245795 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Molchan Susan Unit on Geriatric Psychopharmacology, Section on Clinical Neuropharmacology, Laboratory of Clinical Science, National Institute of Mental Health, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Mellow Alan Department of Psychiatry, University of Michigan Medical Center, 1103 East Huron, 48104, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Lawlor Brian Unit on Geriatric Psychopharmacology, Section on Clinical Neuropharmacology, Laboratory of Clinical Science, National Institute of Mental Health, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Weingartner Herbert Department of Psychology, George Washington University, 2125 G Street, N.W., 20036, Washington, DC, USA aut NATIONALLICENCE 700 1- Cohen Robert Section on Clinical Brain Imaging, Laboratory of Cerebral Metabolism, National Institute of Mental Health, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Cohen Martin Ensor Research Laboratory, William S. Hall Psychiatric Institute, University of South Carolina School of Medicine, P.O. Box 202, 29202, Columbia, SC, USA aut NATIONALLICENCE 700 1- Sunderland Trey Unit on Geriatric Psychopharmacology, Section on Clinical Neuropharmacology, Laboratory of Clinical Science, National Institute of Mental Health, 9000 Rockville Pike, 20892, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/1(1990-03-01), 84-89 0033-3158 100:1<84 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer