caa a22 4500 465738796 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02245786 doi (NATIONALLICENCE)springer-10.1007/BF02245786 Effects of caffeine on alertness [Elektronische Daten] [Ardith Zwyghuizen-Doorenbos, Timothy Roehrs, Lauren Lipschutz, Victoria Timms, Thomas Roth] The alerting effects of caffeine were assessed using a standard physiological measure of daytime sleepiness/alertness, the Multiple Sleep Latency Test (MSLT). Healthy young men (n=24) were randomly assigned to receive caffeine 250 mg or placebo administered double blind, at 0900 and 1300 hours on each of 2 days. On the 3rd day both groups received placebo to test for conditioning to the alerting effects of caffeine. Each day sleep latency was measured at 1000, 1200, 1400, and 1600 hours and performance (divided attention at 1030 hours and auditory vigilance at 1430 hours) was assessed. Caffeine increased sleep latency (i.e., improved alertness) and auditory vigilance performance compared to placebo. Tolerance to the effects of caffeine on sleep latency developed over the four administrations. On the conditioning test (day 3) the group receiving caffeine the previous two days was more alert and performed better than the placebo group. Springer-Verlag, 1990 Multiple sleep latency test nationallicence Caffeine nationallicence Alertness nationallicence Tolerance nationallicence Conditioning nationallicence Zwyghuizen-Doorenbos Ardith Sleep Disorders and Research Center, Henry Ford Hospital, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut Roehrs Timothy Sleep Disorders and Research Center, Henry Ford Hospital, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut Lipschutz Lauren Sleep Disorders and Research Center, Henry Ford Hospital, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut Timms Victoria Sleep Disorders and Research Center, Henry Ford Hospital, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut Roth Thomas Sleep Disorders and Research Center, Henry Ford Hospital, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut Psychopharmacology Springer-Verlag 100/1(1990-03-01), 36-39 0033-3158 100:1<36 1990 100 213 https://doi.org/10.1007/BF02245786 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245786 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zwyghuizen-Doorenbos Ardith Sleep Disorders and Research Center, Henry Ford Hospital, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- Roehrs Timothy Sleep Disorders and Research Center, Henry Ford Hospital, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- Lipschutz Lauren Sleep Disorders and Research Center, Henry Ford Hospital, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- Timms Victoria Sleep Disorders and Research Center, Henry Ford Hospital, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut NATIONALLICENCE 700 1- Roth Thomas Sleep Disorders and Research Center, Henry Ford Hospital, 2921 West Grand Boulevard, 48202, Detroit, MI, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/1(1990-03-01), 36-39 0033-3158 100:1<36 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer