caa a22 4500 46573880X CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02245802 doi (NATIONALLICENCE)springer-10.1007/BF02245802 Behavioral performance effects of nifedipine in normotensive and renovascular hypertensive baboons [Elektronische Daten] [Jaylan Turkkan, Robert Hienz] Behavioral performances of normotensive and hypertensive adult male baboons were tested before, during, and following chronic oral dosing with nifedipine. Performances during a five-color simultaneous match-to-sample task were measured during three dosing schedules (0.20, 0.68, and 1.14 mg/kg/day) and vehicle. Each dose was administered for 21 consecutive days preceded and followed by 14-day baseline and recovery periods, respectively. Choice reaction times increased by 191 ms over baseline at the 0.68 mg/kg dose. Choice reaction times above the 95th percentile (i.e., the slowest reaction times) were the most slowed by nifedipine. Accuracy of color matching was decreased at 0.20 and 0.68 mg/kg by an average range of 2-4%. The yellow and white stimuli were the most difficult to discriminate correctly, and were also the most impaired by nifedipine. Nifedipine's behavioral effects were not modulated by blood pressure changes because daily changes in choice reaction time and systolic blood pressure were not correlated, and hypertensive status did not determine the behavioral effects. Potential sources of nifedipine's behavioral performance effects are discussed, with blood pressure changes excluded as a probable mechanism. Springer-Verlag, 1990 Nifedipine nationallicence Calcium channel blocking agents nationallicence Hypertension nationallicence Antihypertensive agents nationallicence Adverse side-effects nationallicence Non-human primates nationallicence Turkkan Jaylan Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, The Johns Hopkins University School of Medicine, 21205, Baltimore, MD, USA aut Hienz Robert Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, The Johns Hopkins University School of Medicine, 21205, Baltimore, MD, USA aut Psychopharmacology Springer-Verlag 100/1(1990-03-01), 124-129 0033-3158 100:1<124 1990 100 213 https://doi.org/10.1007/BF02245802 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245802 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Turkkan Jaylan Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, The Johns Hopkins University School of Medicine, 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Hienz Robert Department of Psychiatry and Behavioral Sciences, Division of Behavioral Biology, The Johns Hopkins University School of Medicine, 21205, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/1(1990-03-01), 124-129 0033-3158 100:1<124 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer