caa a22 4500 465738818 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02245803 doi (NATIONALLICENCE)springer-10.1007/BF02245803 Oxiracetam and d -pyroglutamic acid antagonize a disruption of passive avoidance behaviour induced by the N-methyl- d -aspartate receptor antagonist 2-amino-5-phosphonovalerate [Elektronische Daten] [F. Paoli, G. Spignoli, G. Pepeu] Intracerebroventricular administration (6 µg/2 µl) ofd-2-amino-5-phosphonovalerate (AP-5), a specific antagonist of the NMDA receptors, prior to training impaired the passive avoidance in a retention test in rat. Pretreatment with oxiracetam andd-pyroglutamic acid at doses ranging from 50 to 500 mg/kg SC dose-dependently prevented the disruptive effect of AP-5. This finding indicates that an interaction with excitatory amino acid NMDA type receptors may be important in behavioural effects of the two pyrrolidinone derivatives. Springer-Verlag, 1990 Nootropic drugs nationallicence d -Pyroglutamic acid nationallicence Oxiracetam nationallicence NMDA receptor nationallicence Passive avoidance nationallicence Rat nationallicence Paoli F. Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Morgagni 65, I-50134, Florence, Italy aut Spignoli G. Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Morgagni 65, I-50134, Florence, Italy aut Pepeu G. Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Morgagni 65, I-50134, Florence, Italy aut Psychopharmacology Springer-Verlag 100/1(1990-03-01), 130-131 0033-3158 100:1<130 1990 100 213 https://doi.org/10.1007/BF02245803 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245803 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Paoli F. Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Morgagni 65, I-50134, Florence, Italy aut NATIONALLICENCE 700 1- Spignoli G. Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Morgagni 65, I-50134, Florence, Italy aut NATIONALLICENCE 700 1- Pepeu G. Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Morgagni 65, I-50134, Florence, Italy aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/1(1990-03-01), 130-131 0033-3158 100:1<130 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer