caa a22 4500 465738834 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02245782 doi (NATIONALLICENCE)springer-10.1007/BF02245782 Differentiation between the stimulus effects of (+)-lysergic acid diethylamide and lisuride using a three-choice, drug discrimination procedure [Elektronische Daten] [Patrick Callahan, James Appel] The discriminative stimulus properties of (+)-lysergic acid diethylamide (LSD) and lisuride hydrogen maleate (LHM), were compared in a three-choice, water reinforced (FR 20) situation in which rats were required to press one lever following LSD (0.08 mg/kg), a second lever following LHM (0.04 mg/kg), and a third lever following saline. Reliable drug-appropriate responding was established in 72 sessions. Dose-response tests with LSD and LHM indicated that, as dose increased, the per cent of responding on the lever associated with the particular training drug also increased; little or no cross-transfer occurred between LSD and LHM. In generalization tests, the serotonin (5-HT) agonist quipazine substituted for LSD but not LHM while the dopamine (DA) agonist apomorphine mimicked LHM but not LSD; an unrelated compound, pentylenetetrazol (PTZ), produced responding on the saline-appropriate lever. In combination tests, 5-HT antagonists (e.g., BC-105 and low doses of pirenperone) blocked responding on the LSD lever while DA antagonists (e.g., haloperidol and much higher doses of pirenperone) blocked LHM-appropriate responding. These data suggest that the three-lever (D-D-N) procedure is similar to, but can be more sensitive than the two-lever (D-N) procedure (because it can differentiate between LSD and LHM); they therefore at least partially support the hypothesis that three-choice discriminations can be conceptualized as two separate, two-choice (D-N) discriminations (Jarbe and Swedberg 1982). The results also confirm suggestion that the stimulus effects of LSD and LHM are mediated by different mechanisms; the primary action of LSD is serotonergic (5-HT2), while that of LHM is dopaminergic (White 1986). Springer-Verlag, 1990 Dopamine nationallicence Drug discrimination nationallicence LSD nationallicence Lisuride nationallicence Serotonin nationallicence Three-choice discrimination nationallicence Callahan Patrick Behavioral Pharmacology Laboratory, Department of Psychology, University of South Carolina, 29208, Columbia, SC, USA aut Appel James Behavioral Pharmacology Laboratory, Department of Psychology, University of South Carolina, 29208, Columbia, SC, USA aut Psychopharmacology Springer-Verlag 100/1(1990-03-01), 13-18 0033-3158 100:1<13 1990 100 213 https://doi.org/10.1007/BF02245782 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245782 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Callahan Patrick Behavioral Pharmacology Laboratory, Department of Psychology, University of South Carolina, 29208, Columbia, SC, USA aut NATIONALLICENCE 700 1- Appel James Behavioral Pharmacology Laboratory, Department of Psychology, University of South Carolina, 29208, Columbia, SC, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/1(1990-03-01), 13-18 0033-3158 100:1<13 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer