caa a22 4500 465738850 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02245798 doi (NATIONALLICENCE)springer-10.1007/BF02245798 ICI 174,864, a selective delta opioid antagonist, reverses the learning impairment produced by [leu]enkephalin [Elektronische Daten] [Gery Schulteis, Joe Martinez Jr.] The role of opioid delta receptors in the learning impairment produced by [leu]enkephalin (LE) in one-way active avoidance conditioning was investigated in mice. LE (30 and 100 µg/kg) impaired acquisition of the avoidance response, whereas ICI 174,864 (3.0 mg/kg), a selective delta opioid receptor antagonist, enhanced acquisition. The impairment produced by 100 µg/kg LE was completely reversed by 1.0 mg/kg ICI 174,864, a dose of the antagonist that by itself had no effect. Control studies provided evidence that the effects of ICI 174,864 and LE on conditioning cannot be explained by performance variables such as alterations in activity levels or footshock sensitivity. The results suggest that opioid delta receptors play an important role in the modulation of learning, and that the effects of LE on avoidance conditioning are mediated by delta receptors. Springer-Verlag, 1990 Learning nationallicence [Leu]enkephalin nationallicence ICI 174,864 nationallicence Delta receptors nationallicence Mice nationallicence Schulteis Gery Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut Martinez Jr. Joe Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut Psychopharmacology Springer-Verlag 100/1(1990-03-01), 102-109 0033-3158 100:1<102 1990 100 213 https://doi.org/10.1007/BF02245798 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245798 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schulteis Gery Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Martinez Jr Joe Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/1(1990-03-01), 102-109 0033-3158 100:1<102 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer