caa a22 4500 465738869 CHVBK 20180323111802.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02244600 doi (NATIONALLICENCE)springer-10.1007/BF02244600 Reduced behavioral variability in extinction: effects of chronic treatment with the benzodiazepine, diazepam or with ethanol [Elektronische Daten] [Charles Beck, Elliot Loh] Extinction of a food reinforced habit results in an increase in the variability of the response learned in acquisition and in the appearance of previously suppressed competing responses. The purpose of the present study was to examine the effects of chronically administered diazepam (0.0, 1.5, 3.0, or 6.0 mg/kg, IP, −30 min) or 10% ethanol (0.0, 1.0, 1.5, or 2.0 g/kg, IP, −15 min) on such behavioral variability in the extinction of radial maze performance. Eight groups of food deprived rats (n=6) were given one of the forementioned doses for 2 sessions of baseline, 18 sessions of acquisition, and 5 sessions of extinction. In acquisition, eight rewards of two food pellets were obtained on each of three trials in each session. The food well at the end of each arm was rebaited when empited by the animal, consequently an entry into any arm was reinforced. In base-line and extinction no food was available in the maze. Each session consisted of three 10-min trials. In extinction, compared to treatment with vehicle, both diazepam and ethanol treatments decreased the rate of the instrumental response, arm entry, and increased the variability of the instrumental response and of competing responses. Only the effects of the drugs on the competing responses in extinction were greater than those observed in acquisition. It was concluded that the interference-reduction model of drug action best described the magnitude of the drug effects and the variability-reduction model best predicted the direction of the effects. Springer-Verlag, 1990 Benzodiazepine nationallicence Ethanol nationallicence Radial maze nationallicence Extinction nationallicence Behavioral variability nationallicence Beck Charles Department of Psychology, University of Alberta, T6G 2E9, Edmonton, Alberta, Canada aut Loh Elliot Department of Psychology, University of Alberta, T6G 2E9, Edmonton, Alberta, Canada aut Psychopharmacology Springer-Verlag 100/3(1990-03-01), 323-327 0033-3158 100:3<323 1990 100 213 https://doi.org/10.1007/BF02244600 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244600 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Beck Charles Department of Psychology, University of Alberta, T6G 2E9, Edmonton, Alberta, Canada aut NATIONALLICENCE 700 1- Loh Elliot Department of Psychology, University of Alberta, T6G 2E9, Edmonton, Alberta, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/3(1990-03-01), 323-327 0033-3158 100:3<323 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer