caa a22 4500 465738877 CHVBK 20180323111803.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02244602 doi (NATIONALLICENCE)springer-10.1007/BF02244602 Aspects of amitriptyline and nortriptyline plasma levels monitoring in depression [Elektronische Daten] [Gian Corona, Maria Cucchi, Pietro Frattini, Giuseppe Santagostino, Sergio Schinelli, Francesco Zerbi, Faustino Savoldi] Fifty-nine depressed female inpatients were treated with 100 mg amitriptiline (AMT) IM for 4 weeks. Depression ratings and determinations of the parent drug and nortriptyline (NT) were performed weekly. No direct relationship between plasma AMT + NT concentrations and therapeutic response was apparent, but beneficial therapeutic responses and significantly lower side-effect scores were more frequently noted in subjects with concentrations in the 100-200 ng/ml range. AMT + NT concentrations were significantly correlated with age. No significant difference was found in the number of responders between younger and older subjects with two clinical improvement criteria; however, a significant difference emerged when a third more restrictive clinical outcome criterion was adopted. The implications of the present findings for patient treatment and for the interpretation of previous studies are discussed. The data collected point to a possible usefulness of monitoring AMT and NT plasma levels, even if further investigations are needed. Springer-Verlag, 1990 Amitriptyline nationallicence Nortriptyline nationallicence Monitoring nationallicence Depression nationallicence Corona Gian Institute of Pharmacology, University of Pavia, Via Taramelli 14, I-27100, Pavia, Italy aut Cucchi Maria Institute of Pharmacology, University of Pavia, Via Taramelli 14, I-27100, Pavia, Italy aut Frattini Pietro Institute of Pharmacology, University of Pavia, Via Taramelli 14, I-27100, Pavia, Italy aut Santagostino Giuseppe Institute of Pharmacology, University of Pavia, Via Taramelli 14, I-27100, Pavia, Italy aut Schinelli Sergio Institute of Pharmacology, University of Pavia, Via Taramelli 14, I-27100, Pavia, Italy aut Zerbi Francesco Department of Neurology, University of Pavia, Via Palestro 3, I-27100, Pavia, Italy aut Savoldi Faustino Department of Neurology, University of Pavia, Via Palestro 3, I-27100, Pavia, Italy aut Psychopharmacology Springer-Verlag 100/3(1990-03-01), 334-338 0033-3158 100:3<334 1990 100 213 https://doi.org/10.1007/BF02244602 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244602 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Corona Gian Institute of Pharmacology, University of Pavia, Via Taramelli 14, I-27100, Pavia, Italy aut NATIONALLICENCE 700 1- Cucchi Maria Institute of Pharmacology, University of Pavia, Via Taramelli 14, I-27100, Pavia, Italy aut NATIONALLICENCE 700 1- Frattini Pietro Institute of Pharmacology, University of Pavia, Via Taramelli 14, I-27100, Pavia, Italy aut NATIONALLICENCE 700 1- Santagostino Giuseppe Institute of Pharmacology, University of Pavia, Via Taramelli 14, I-27100, Pavia, Italy aut NATIONALLICENCE 700 1- Schinelli Sergio Institute of Pharmacology, University of Pavia, Via Taramelli 14, I-27100, Pavia, Italy aut NATIONALLICENCE 700 1- Zerbi Francesco Department of Neurology, University of Pavia, Via Palestro 3, I-27100, Pavia, Italy aut NATIONALLICENCE 700 1- Savoldi Faustino Department of Neurology, University of Pavia, Via Palestro 3, I-27100, Pavia, Italy aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/3(1990-03-01), 334-338 0033-3158 100:3<334 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer