caa a22 4500 465738885 CHVBK 20180323111803.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02244595 doi (NATIONALLICENCE)springer-10.1007/BF02244595 Benzodiazepine anti-conflict effects in maudsley reactive (MR/Har) and non-reactive (MNRA/Har) rats [Elektronische Daten] [Randall Commissaris, Gordon Harrington, Harvey Altman] The Maudsley Reactive (MR/Har) and Non-Reactive (MNRA/Har) rat strains, bred originally by Broadhurst for differences in Open Field Defecation, also differ in their control (i.e., non-drug) behavior in the Conditioned Suppression of Drinking (CSD) conflict procedure, a second "model” behavior for the study of anxiety and/or emotionality in rats. The present studies compared the effects of diazepam and alprazolam on CSD behavior in these two strains of rats. In daily 10-min sessions, water-deprived rats were trained to drink from a tube that was occasionally electrified (0.2-0.5 mA), electrification being signaled by a tone. Both diazepam and alprazolam increased punished responding in a dose-related manner. The per cent increase in punished responding (for diazepam only) was comparable in the two strains; however, both statistical and empirical approaches indicated that the magnitude of the anti-conflict effect of benzodiazepines in MNRA/Har versus MR/Har rats was not related to differences in baseline (i.e., non-drug) punished responding. Based on the absolute change in shocks received, rats of the MNRA/Har strain exhibited a significantly greater anti-conflict effect following diazepam or alprazolam treatment than did rats of the MR/Har strain. These findings further the hypothesis that the behavioral differences exhibited by Maudsley MR/Har and MNRA/Har rat strains may constitute a genetically-based "animal model” for the study of emotionality and/or anxiety. Springer-Verlag, 1990 MR/Har and MNRA/Har Maudsley rat strains nationallicence Conflict behavior nationallicence Anxiety nationallicence Alprazolam nationallicence Diazepam nationallicence Benzodiazepines nationallicence Commissaris Randall Department of Pharmaceutical Sciences, College of Pharmacy & AHP, 1400 Chrysler Avenue, USA aut Harrington Gordon Department of Psychology, University of Northern Iowa, 50614, Cedar Falls, IA, USA aut Altman Harvey Department of Psychiatry, School of Medicine, Wayne State University, 540 East Canfield Avenue, 48202, Detroit, MI, USA aut Psychopharmacology Springer-Verlag 100/3(1990-03-01), 287-292 0033-3158 100:3<287 1990 100 213 https://doi.org/10.1007/BF02244595 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244595 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Commissaris Randall Department of Pharmaceutical Sciences, College of Pharmacy & AHP, 1400 Chrysler Avenue, USA aut NATIONALLICENCE 700 1- Harrington Gordon Department of Psychology, University of Northern Iowa, 50614, Cedar Falls, IA, USA aut NATIONALLICENCE 700 1- Altman Harvey Department of Psychiatry, School of Medicine, Wayne State University, 540 East Canfield Avenue, 48202, Detroit, MI, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/3(1990-03-01), 287-292 0033-3158 100:3<287 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer