caa a22 4500 46573894X CHVBK 20180323111803.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02244610 doi (NATIONALLICENCE)springer-10.1007/BF02244610 Ontogeny of the enhanced behavioral response to amphetamine in amphetamine-pretreated rats [Elektronische Daten] [M. Kolta, F. Scalzo, S. Ali, R. Holson] Repeated administration of amphetamine to adult rats results in enhanced behavioral responses to subsequent amphetamine exposure. These experiments were designed to determine the earliest age at which behavioral sensitization to amphetamine could be detected. Rats from both sexes (n=6-8/group) at ages of 1, 7, 21 or 49 postnatal days (PNDs) were injected with eitherd-amphetamine sulfate (5 mg/kg) or saline, SC, twice daily for 5 consecutive days. Stereotyped behavior and locomotor activity responses to a challenge dose ofd-amphetamine (2.5 mg/kg), or saline, IP, were assessed for a total of 90 min, 15 days after the last dose of pretreatment. Amphetamine-induced stereotyped behavior was significantly enhanced only when amphetamine pretreatment was initiated at PND 49, but not at the earlier ages of PND 1, 7 or 21. There was no apparent sex difference in this effect. Correspondingly, amphetamine-induced locomotor activity was reduced in both sexes of the same age group (PND 49), but not in gropus pretreated earlier, when compared to the saline-pretreated rats. These results sugges that amphetamine sensitization may be a late-developing effect, one which occurs sometime after the 3rd week of postnatal life. Springer-Verlag, 1990 Ontogeny nationallicence Behavioral sensitization nationallicence Amphetamine nationallicence Neonatal rats nationallicence Kolta M. College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, 32307, Tallahassee, FL, USA aut Scalzo F. Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, 72079-9502, Jefferson, AR, USA aut Ali S. Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, 72079-9502, Jefferson, AR, USA aut Holson R. Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, 72079-9502, Jefferson, AR, USA aut Psychopharmacology Springer-Verlag 100/3(1990-03-01), 377-382 0033-3158 100:3<377 1990 100 213 https://doi.org/10.1007/BF02244610 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244610 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kolta M. College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, 32307, Tallahassee, FL, USA aut NATIONALLICENCE 700 1- Scalzo F. Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, 72079-9502, Jefferson, AR, USA aut NATIONALLICENCE 700 1- Ali S. Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, 72079-9502, Jefferson, AR, USA aut NATIONALLICENCE 700 1- Holson R. Division of Reproductive and Developmental Toxicology, National Center for Toxicological Research, 72079-9502, Jefferson, AR, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/3(1990-03-01), 377-382 0033-3158 100:3<377 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer