caa a22 4500 465738966 CHVBK 20180323111803.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02244598 doi (NATIONALLICENCE)springer-10.1007/BF02244598 Reinforcing effects of peripherally administered substance P and its C-terminal sequence pGlu6-SP6-11 in the rat [Elektronische Daten] [M. Oitzl, R. Hasenöhrl, J. Huston] Reinforcing effects of intraperitoneally (IP) administered substance P (SP1-11), its amino-terminal fragment SP1-7 (SPN) and an analog of the carboxy terminus (pGlu6-SP6-11: SPC) were studied in rats. Two conditioned place preference paradigms were used. After three pairings of the drug with a certain environment the effect of the treatment was evaluated in the drug-free state during a test trial. The reinforcing effects of SP (37 nmol) and the equimolar dose of SPC were expressed by a significant increase in the amount of time the animals spent in the treatment environment. Other doses of SP (3.7 and 185 nmol) and SPC (7.4 and 185 nmol) and none of the doses of SPN (37, 185, 370 nmol) influenced the place preference behavior of the rats. The reinforcing effects of SP parallel the known facilitating effects of peripherally administered SP on memory. The amino acids that encode the reinforcing effects of SP may lie within the C-terminal sequence of the SP molecule. Springer-Verlag, 1990 Substance P nationallicence Reinforcement nationallicence SP fragments nationallicence Structure-activity nationallicence Conditioned place preference nationallicence Rat nationallicence Oitzl M. Institute of Physiological Psychology, University of Düsseldorf, Universitätsstrasse 1, D-4000, Düsseldorf, Germany aut Hasenöhrl R. Institute of Physiological Psychology, University of Düsseldorf, Universitätsstrasse 1, D-4000, Düsseldorf, Germany aut Huston J. Institute of Physiological Psychology, University of Düsseldorf, Universitätsstrasse 1, D-4000, Düsseldorf, Germany aut Psychopharmacology Springer-Verlag 100/3(1990-03-01), 308-315 0033-3158 100:3<308 1990 100 213 https://doi.org/10.1007/BF02244598 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244598 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oitzl M. Institute of Physiological Psychology, University of Düsseldorf, Universitätsstrasse 1, D-4000, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Hasenöhrl R. Institute of Physiological Psychology, University of Düsseldorf, Universitätsstrasse 1, D-4000, Düsseldorf, Germany aut NATIONALLICENCE 700 1- Huston J. Institute of Physiological Psychology, University of Düsseldorf, Universitätsstrasse 1, D-4000, Düsseldorf, Germany aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/3(1990-03-01), 308-315 0033-3158 100:3<308 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer