caa a22 4500 465738974 CHVBK 20180323111803.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02244618 doi (NATIONALLICENCE)springer-10.1007/BF02244618 Effects of nalmefene on feeding in humans [Elektronische Daten] Dissociation of hunger and palatability [M. Yeomans, P. Wright, H. Macleod, J. Critchley] Effects of nalmefene on eating were investigated in two groups of ten male volunteers, in a double-blind placebo-controlled study. The nalmefene treated group ate 22% less, both in terms of absolute weight and caloric intake, of a standardised buffet-meal than did the placebo group. No differences in subjective ratings of hunger or satiety were found between the groups, suggesting that the reduced feeding was not a consequence of any change in motivation to eat. When analysed by nutrient content, nalmefene was found to reduce fat and protein, but not carbohydrate, intakes. Analyses of intakes of individual foods showed a differential effect of nalmefene on foods rated as highly palatable. Thus the apparent nutrient specificity of nalmefene appeared to be an indirect consequence of its effect on palatability. Nalmefene also caused slight increases in self-rated alertness, and decreases in ratings of tiredness and elation, although it was thought unlikely that these accounted for observed changes in eating behaviour. No other side-effects were detected, and performance on a choice reaction time task was unaffected. These results add weight to suggestions that endogenous opioids are involved in reward-related aspects of feeding associated with food palatability. Springer-Verlag, 1990 Feeding nationallicence Humans nationallicence Opioids nationallicence Nalmefene nationallicence Palatability nationallicence Yeomans M. Department of Psychology, University of Edinburgh, 7 George Square, EH8 9JZ, Edinburgh, UK aut Wright P. Department of Psychology, University of Edinburgh, 7 George Square, EH8 9JZ, Edinburgh, UK aut Macleod H. Department of Psychology, University of Edinburgh, 7 George Square, EH8 9JZ, Edinburgh, UK aut Critchley J. Department of Clinical Pharmacology, Royal Infirmary, Lauriston Place, EH3 9YW, Edinburgh, UK aut Psychopharmacology Springer-Verlag 100/3(1990-03-01), 426-432 0033-3158 100:3<426 1990 100 213 https://doi.org/10.1007/BF02244618 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244618 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yeomans M. Department of Psychology, University of Edinburgh, 7 George Square, EH8 9JZ, Edinburgh, UK aut NATIONALLICENCE 700 1- Wright P. Department of Psychology, University of Edinburgh, 7 George Square, EH8 9JZ, Edinburgh, UK aut NATIONALLICENCE 700 1- Macleod H. Department of Psychology, University of Edinburgh, 7 George Square, EH8 9JZ, Edinburgh, UK aut NATIONALLICENCE 700 1- Critchley J. Department of Clinical Pharmacology, Royal Infirmary, Lauriston Place, EH3 9YW, Edinburgh, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/3(1990-03-01), 426-432 0033-3158 100:3<426 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer