caa a22 4500 465739008 CHVBK 20180323111803.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02244615 doi (NATIONALLICENCE)springer-10.1007/BF02244615 Intermittent and continuous haloperidol regimens produce different types of oral dyskinesias in rats [Elektronische Daten] [Ronald See, Gaylord Ellison] Rats were administered equivalent doses of haloperidol for either 28 days or 8 months using one of two different drug regimens: intermittent (i.e., weekly injections) or continuously (via drinking water and osmotic minipumps). Oral movements were determined by human observers and by a computerized video analysis system, which determined number and amplitude of jaw openings and closings (computer-scored movelets "CSMs”) as well as the slope (amplitude/duration) and frequency spectrum (fourier transform) of oral activity. The two drug groups developed distinctively different changes over time. Continuous administration resulted in late-onset oral activity changes at 1-3 Hz and withdrawal increases in CSMs, a pattern expected of tardive dyskinesia. Intermittent treatment produced a primed dystonia-like pattern: large amplitude CSMs which had steep onset slopes and a peak energy at 4-7 Hz. These results demonstrate the importance of drug regimen in determining the type of neuroleptic-induced dyskinesias which develop with prolonged neuroleptic treatment in rodents. Springer-Verlag, 1990 Neuroleptics nationallicence Haloperidol nationallicence Tardive dyskinesia nationallicence Dystonia nationallicence Animal models nationallicence Rats nationallicence See Ronald Department of Psychology, University of California, 90024, Los Angeles, CA, USA aut Ellison Gaylord Department of Psychology, University of California, 90024, Los Angeles, CA, USA aut Psychopharmacology Springer-Verlag 100/3(1990-03-01), 404-412 0033-3158 100:3<404 1990 100 213 https://doi.org/10.1007/BF02244615 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244615 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- See Ronald Department of Psychology, University of California, 90024, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Ellison Gaylord Department of Psychology, University of California, 90024, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/3(1990-03-01), 404-412 0033-3158 100:3<404 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer