caa a22 4500 465739024 CHVBK 20180323111803.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02244612 doi (NATIONALLICENCE)springer-10.1007/BF02244612 Effects of dihydropyridine calcium channel antagonists in ethanol withdrawal; doses required, stereospecificity and actions of Bay K 8644 [Elektronische Daten] [J. Littleton, H. Little, M. Whittington] The effects of dihydropyridine calcium channel antagonists, and the calcium channel activator, Bay K 8644, were examined on the convulsive behaviour induced by handling in mice following withdrawal from chronic ethanol inhalation. Nimodipine and nitrendipine and PN 200-110 significantly decreased the convulsive behaviour, after intraperitoneal doses of the same order of magnitude as have been found by others to be required for displacement of radiolabelled dihydropyridine in the CNS. The (+) isomer of PN 200-110 was effective, but the (−) isomer, which is ineffective in vitro, had no significant action. Bay K 8644 prevented the actions of nimodipine against the ethanol withdrawal syndrome. The behavioural ratings after nimodipine plus Bay K 8644 were significantly higher than after vehicle treatment. Bay K 8644 alone, when given to naive mice, caused convulsive behaviour resembling that seen in withdrawal from chronic ethanol treatment, but when given during ethanol withdrawal did not significantly increase the behavioural signs. Springer-Verlag, 1990 Calcium channel antagonists nationallicence Bay K 8644 nationallicence Nimodipine nationallicence Nitrendipine nationallicence PN 200-110 nationallicence Littleton J. Department of Pharmacology, Kings College, The Strand, London, UK aut Little H. Department of Pharmacology, The Medical School, University Walk, BS8 1TD, Bristol, UK aut Whittington M. Department of Pharmacology, The Medical School, University Walk, BS8 1TD, Bristol, UK aut Psychopharmacology Springer-Verlag 100/3(1990-03-01), 387-392 0033-3158 100:3<387 1990 100 213 https://doi.org/10.1007/BF02244612 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244612 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Littleton J. Department of Pharmacology, Kings College, The Strand, London, UK aut NATIONALLICENCE 700 1- Little H. Department of Pharmacology, The Medical School, University Walk, BS8 1TD, Bristol, UK aut NATIONALLICENCE 700 1- Whittington M. Department of Pharmacology, The Medical School, University Walk, BS8 1TD, Bristol, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/3(1990-03-01), 387-392 0033-3158 100:3<387 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer