caa a22 4500 465739032 CHVBK 20180323111803.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02244609 doi (NATIONALLICENCE)springer-10.1007/BF02244609 5-HT1C receptors in the serotonergic control of periaqueductal gray induced aversion in rats [Elektronische Daten] [François Jenck, Chris Broekkamp, Anton Van Delft] The functional role of brain 5-HT and 5-HT receptor subtypes in periaqueductal gray (PAG) induced aversion has been investigated in rats. Antiaversive effects were found with the serotonin agonists TFMPP, mCPP and DOI but not with RU 24969 which was found to facilitate PAG aversion. The first three serotonin agonists share potent 5-HT1C activity while RU 24969 differs with a high 5-HT1A activity. Proaversive effects were found with the mixed 5-HT1C/5-HT2 antagonists cyproheptadine and ritanserin; this effect was already reported for the mixed 5-HT1C/5-HT2 antagonists metergoline and mianserin and is opposite to the effects of the selective 5-HT2 antagonists ketanserin, pirenperone, trazodone and spiperone. The antiaversive effects of mCPP (1 mg/kg) could be prevented by pretreatment of the animals with mianserin (1 and 10 mg/kg). These results suggest that 5-HT1C receptors play an important role in the serotonergic control of PAG aversion. 5-HT1C receptor activation seems to mediate antiaversive effects whereas acute 5-HT1C receptor blockade appears to facilitate PAG aversion. Functional interactions take place between several receptor types in the in vivo control of PAG aversion, where 5-HT1C receptors appear to play a predominant function. Springer-Verlag, 1990 Serotonin nationallicence 5-HT1C receptor nationallicence Periaqueductal gray nationallicence Aversion nationallicence Anxiety nationallicence Rat nationallicence Jenck François CNS Pharmacology Department, Organon International, P.O. Box 20, NL-5340 BH, OSS, The Netherlands aut Broekkamp Chris CNS Pharmacology Department, Organon International, P.O. Box 20, NL-5340 BH, OSS, The Netherlands aut Van Delft Anton CNS Pharmacology Department, Organon International, P.O. Box 20, NL-5340 BH, OSS, The Netherlands aut Psychopharmacology Springer-Verlag 100/3(1990-03-01), 372-376 0033-3158 100:3<372 1990 100 213 https://doi.org/10.1007/BF02244609 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244609 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jenck François CNS Pharmacology Department, Organon International, P.O. Box 20, NL-5340 BH, OSS, The Netherlands aut NATIONALLICENCE 700 1- Broekkamp Chris CNS Pharmacology Department, Organon International, P.O. Box 20, NL-5340 BH, OSS, The Netherlands aut NATIONALLICENCE 700 1- Van Delft Anton CNS Pharmacology Department, Organon International, P.O. Box 20, NL-5340 BH, OSS, The Netherlands aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/3(1990-03-01), 372-376 0033-3158 100:3<372 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer