caa a22 4500 465739067 CHVBK 20180323111803.0 cr unu---uuuuu 170327e19900301xx s 000 0 eng 10.1007/BF02244616 doi (NATIONALLICENCE)springer-10.1007/BF02244616 Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine [Elektronische Daten] [N. Swerdlow, R. Mansbach, M. Geyer, L. Pulvirenti, G. Koob, D. Braff] Previous studies have demonstrated that dopamine (DA) agonists disrupt sensorimotor gating as measured by prepulse inhibition (PPI) of the acoustic startle response (ASR) in rats; other reports suggest that this stimulant-induced disruption of PPI may reflect drug-induced increases in ASR amplitude rather than changes in sensorimotor gating. In the current study, 6-hydroxydopamine lesions that depleted dopamine from the nucleus accumbens, olfactory tubercles and anterior striatum reversed the disruption of PPI caused by amphetamine (AMPH), but did not disrupt AMPH potentiation of ASR baseline. These findings strongly suggest that increased mesolimbic DA activity is one substrate of the AMPH-induced disruption of PPI; in contrast, AMPH potentiation of baseline startle amplitude may be independent of mesolimbic DA activation. Springer-Verlag, 1990 Acoustic startle response nationallicence Dopamine nationallicence Nucleus accumbens nationallicence Prepulse inhibition nationallicence Schizophrenia nationallicence Swerdlow N. Department of Psychiatry, M003, University of California at San Diego, 92093, La Jolla, CA, USA aut Mansbach R. Department of Pharmacology and Toxicology, Medical College of Virginia, MCV Station, Box 613, 23298, Richmond, VA, USA aut Geyer M. Department of Psychiatry, M003, University of California at San Diego, 92093, La Jolla, CA, USA aut Pulvirenti L. 3rd Department of Neurology, University of Pavia, Italy aut Koob G. Preclinical Neuroscience, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Braff D. Department of Psychiatry, M003, University of California at San Diego, 92093, La Jolla, CA, USA aut Psychopharmacology Springer-Verlag 100/3(1990-03-01), 413-416 0033-3158 100:3<413 1990 100 213 https://doi.org/10.1007/BF02244616 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244616 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Swerdlow N. Department of Psychiatry, M003, University of California at San Diego, 92093, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Mansbach R. Department of Pharmacology and Toxicology, Medical College of Virginia, MCV Station, Box 613, 23298, Richmond, VA, USA aut NATIONALLICENCE 700 1- Geyer M. Department of Psychiatry, M003, University of California at San Diego, 92093, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Pulvirenti L. 3rd Department of Neurology, University of Pavia, Italy aut NATIONALLICENCE 700 1- Koob G. Preclinical Neuroscience, Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Braff D. Department of Psychiatry, M003, University of California at San Diego, 92093, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/3(1990-03-01), 413-416 0033-3158 100:3<413 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer