caa a22 4500 465739148 CHVBK 20180323111803.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF02243997 doi (NATIONALLICENCE)springer-10.1007/BF02243997 Behavioral effects after intrathecal administration of cholinergic receptor agonists in the rat [Elektronische Daten] [P. Gillberg, P. Hartvig, T. Gordh, A. Sottile, I. Jansson, T. Archer, C. Post] Behavioral effects of nicotine and cytisine, and the cholinesterase inhibitors physostigmine and 9-amino-1,2,3,4-tetrahydroacridine (THA), administered intrathecally (IT) at the lumbar level in the rat have been evaluated. Antinociceptive dose relationships were established using the tail immersion test. Total activity, locomotion and rearing were also measured in computerized test boxes. The nicotinic receptor antagonist, mecamylamine, and the muscarinic receptor antagonist, atropine, were used to study the selectivity of the effects. Physostigmine and THA significantly decreased total activity, locomotion and rearing as compared to control animals. The motor effects of physostigmine were completely antagonized by atropine whereas those of THA were antagonized only partly. Mecamylamine had no antagonistic effect. Nicotine did not affect any activity parameter. Cytisin reduced total activity and locomotion 1-6 min after dose. IT physostigmine, 15 µg, increased tail immersion latency for 30 min. No significant increase in response latency in this test was observed after the IT administration of nicotine or THA, whereas cytisine elicited a small increase. The IT administration of THA, nicotine and cytisine was also associated with gnawing, vocalization and hyperactivity and in the case of THA, diarrhoea. These effects were blocked by mecamylamine. Physostigmine antinociception as well as the behavioral effects including total activity, locomotion and rearing caused by physostigmine and by THA are most probably due to an action on spinal muscarinic receptors. Nicotinic receptors do not seem to be involved in spinal antinociception. Some aversive behavioral effects caused by the IT administration of nicotinic receptor agonists could, however, be attenuated by the spinal administration of the antagonist mecamylamine, which may indicate the involvement of nicotinic receptors in afferent sensory transmission. Springer-Verlag, 1990 Nicotine nationallicence Cytisine nationallicence 9-Amino-1,2,3,4-tetrahydroacridine nationallicence Physostigmine nationallicence Intrathecal administration nationallicence Gillberg P. Department of Neurology, University Hospital, S-751 85, Uppsala, Sweden aut Hartvig P. Department of Hospital Pharmacy, University Hospital, S-751 85, Uppsala, Sweden aut Gordh T. Department of Anesthesiology, University Hospital, S-751 85, Uppsala, Sweden aut Sottile A. Department of Anesthesiology, University Hospital, S-751 85, Uppsala, Sweden aut Jansson I. Department of Anesthesiology, University Hospital, S-751 85, Uppsala, Sweden aut Archer T. Department of Psychology, University of Gothenburg, Box 14158, S-400 20, Gothenburg, Sweden aut Post C. Research and Development Department, AB Astra, S-151 85, Södertälje, Sweden aut Psychopharmacology Springer-Verlag 100/4(1990-04-01), 464-469 0033-3158 100:4<464 1990 100 213 https://doi.org/10.1007/BF02243997 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02243997 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gillberg P. Department of Neurology, University Hospital, S-751 85, Uppsala, Sweden aut NATIONALLICENCE 700 1- Hartvig P. Department of Hospital Pharmacy, University Hospital, S-751 85, Uppsala, Sweden aut NATIONALLICENCE 700 1- Gordh T. Department of Anesthesiology, University Hospital, S-751 85, Uppsala, Sweden aut NATIONALLICENCE 700 1- Sottile A. Department of Anesthesiology, University Hospital, S-751 85, Uppsala, Sweden aut NATIONALLICENCE 700 1- Jansson I. Department of Anesthesiology, University Hospital, S-751 85, Uppsala, Sweden aut NATIONALLICENCE 700 1- Archer T. Department of Psychology, University of Gothenburg, Box 14158, S-400 20, Gothenburg, Sweden aut NATIONALLICENCE 700 1- Post C. Research and Development Department, AB Astra, S-151 85, Södertälje, Sweden aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/4(1990-04-01), 464-469 0033-3158 100:4<464 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer