caa a22 4500 465739156 CHVBK 20180323111803.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF02244005 doi (NATIONALLICENCE)springer-10.1007/BF02244005 A comparison of the effects of scopolamine and diazepam on acquisition and retention of inhibitory avoidance in mice [Elektronische Daten] [Michael Decker, Thuy Tran, James McGaugh] Administration of either the muscarinic antagonist scopolamine or the benzodiazepine diazepam prior to training produced a dose-dependent impairment in the retention of one-trial inhibitory avoidance training in mice. To investigate the nature of this drug effect, the effects of scopolamine and diazepam were subsequently assessed on both acquisition and retention of inhibitory avoidance using a multiple-trial, training-to-criterion procedure. The training was conducted using either continuous trials in which the mouse was free to shuttle back and forth between shock and safe compartments or discrete trials in which the mouse was moved from the shock compartment of the safe compartment at the start of each trial. In either case, training continued until the mouse refrained from crossing into the shock compartment for a specified length of time on a single trial. Scopolamine (1.0 mg/kg) administered before training significantly increased the number of trials required to attain criterion, but did not affect retention when these mice were tested 2, 16, or 28 days later. In contrast, diazepam (1.0 mg/kg) did not significantly alter the number of trials necessary to reach criterion, but impaired retention of the inhibitory response in mice trained using discrete trials. The differences in the amnestic effects of scopolamine and diazepam revealed by this detailed analysis suggest that diazepam does not impair inhibitory avoidance performance through an effect on cholinergic function. Springer-Verlag, 1990 Inhibitory (passive) avoidance nationallicence Memory nationallicence Mice nationallicence Acetylcholine nationallicence Benzodiazepines nationallicence Decker Michael Department of Psychobiology and Center for the Neurobiology of Learning and Memory, University of California, 92717, Irvine, CA, USA aut Tran Thuy Department of Psychobiology and Center for the Neurobiology of Learning and Memory, University of California, 92717, Irvine, CA, USA aut McGaugh James Department of Psychobiology and Center for the Neurobiology of Learning and Memory, University of California, 92717, Irvine, CA, USA aut Psychopharmacology Springer-Verlag 100/4(1990-04-01), 515-521 0033-3158 100:4<515 1990 100 213 https://doi.org/10.1007/BF02244005 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244005 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Decker Michael Department of Psychobiology and Center for the Neurobiology of Learning and Memory, University of California, 92717, Irvine, CA, USA aut NATIONALLICENCE 700 1- Tran Thuy Department of Psychobiology and Center for the Neurobiology of Learning and Memory, University of California, 92717, Irvine, CA, USA aut NATIONALLICENCE 700 1- McGaugh James Department of Psychobiology and Center for the Neurobiology of Learning and Memory, University of California, 92717, Irvine, CA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/4(1990-04-01), 515-521 0033-3158 100:4<515 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer