caa a22 4500 465739164 CHVBK 20180323111803.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF02243996 doi (NATIONALLICENCE)springer-10.1007/BF02243996 Blockade of acquisition of drug-conditioned place aversion by 5HT3 antagonists [Elektronische Daten] [E. Acquas, E. Carboni, L. Garau, G. Di Chiara] The effect of two 5HT3 antagonists, ICS 205-930 and MDL 72222, on drug-induced place aversion was studied in a two-compartment apparatus with a procedure including a pre-test for spontaneous preference. Naloxone (0.8 mg/kg SC), phencyclidine (2.5 mg/kg SC) and picrotoxin (2.0 mg/kg IP) paired with the preferred compartment elicited a significant place aversion. ICS 205-930 and MDL 72222 failed to modify spontaneous place preference when paired with both compartments. ICS 205-930 (30 µg/kg SC) paired with the preferred and, in other experiments, with the non-preferred compartment, also failed to modify spontaneous preference. ICS 205-930 (7.5, 15 and 30 µg/kg SC), paired with both compartments, dose-dependently reduced the place aversion induced by naloxone (0.8 mg/kg SC), phencyclidine (2.5 mg/kg SC) and picrotoxin (2.0 mg/kg IP). MDL 72222 (30 µg/kg SC) paired with both compartments had a similar effect. The result indicate that 5HT, via 5HT3 receptors, plays a role in the aversive properties of drug stimuli. Springer-Verlag, 1990 5-HT nationallicence 5HT3 antagonist nationallicence Naloxone nationallicence Phencyclidine nationallicence Picrotoxin nationallicence Acquas E. Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Viale A. Diaz 182, I-09126, Cagliari, Italy aut Carboni E. Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Viale A. Diaz 182, I-09126, Cagliari, Italy aut Garau L. Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Viale A. Diaz 182, I-09126, Cagliari, Italy aut Di Chiara G. Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Viale A. Diaz 182, I-09126, Cagliari, Italy aut Psychopharmacology Springer-Verlag 100/4(1990-04-01), 459-463 0033-3158 100:4<459 1990 100 213 https://doi.org/10.1007/BF02243996 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02243996 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Acquas E. Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Viale A. Diaz 182, I-09126, Cagliari, Italy aut NATIONALLICENCE 700 1- Carboni E. Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Viale A. Diaz 182, I-09126, Cagliari, Italy aut NATIONALLICENCE 700 1- Garau L. Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Viale A. Diaz 182, I-09126, Cagliari, Italy aut NATIONALLICENCE 700 1- Di Chiara G. Institute of Experimental Pharmacology and Toxicology, University of Cagliari, Viale A. Diaz 182, I-09126, Cagliari, Italy aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/4(1990-04-01), 459-463 0033-3158 100:4<459 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer