caa a22 4500 465739202 CHVBK 20180323111803.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF02244009 doi (NATIONALLICENCE)springer-10.1007/BF02244009 Behavioral evidence implicating dopamine in sensorimotor arousal and norepinephrine in the sedative effects of antidepressant drugs [Elektronische Daten] [Larry Kokkinidis, Bryon McCarter] The effects of acute and chronic antidepressant treatment on acoustic startle were evaluated in three experiments. Administration of 2.5-10.0 mg/kg desipramine, amitriptyline, and nortriptyline depressed acoustic startle responding after repeated sensory stimulation. In contrast to the tricyclic drugs, the serotonin reuptake inhibitor zimelidine increased acoustic startle, and inhibition of dopamine reuptake following acute nomifensine and bupropion administration did not influence startle reactivity in the doses examined. The response reducing effects of desipramine and amitriptyline persisted following chronic exposure to these drugs, and these findings were discussed in relation to the inhibitory actions of the tricyclics on locus coeruleus neurons. A second major finding in this study was that animals challenged withd-amphetamine during desipramine and amitriptyline withdrawal showed a facilitated startle response. Enhanced startle reactivity to amphetamine was also observed following long-term exposure to iprindole, and a withdrawal hyperactivity of acoustic startle was evident after chronic treatment with amoxapine, bupropion, and nomifensine. These results agree with evidence that repeated administration of antidepressants increases dopamine neurotransmission which modulates sensorimotor arousal. Springer-Verlag, 1990 Sensorimotor reactivity nationallicence Antidepressants nationallicence Amphetamine nationallicence Dopamine (DA) nationallicence Serotonin (5-HT) nationallicence Norepinephrine (NE) nationallicence Locus coeruleus (LC) nationallicence Kokkinidis Larry Department of Psychology, University of Saskatchewan, S7N OWO, Saskatoon, Saskatchewan, Canada aut McCarter Bryon Department of Psychology, University of Saskatchewan, S7N OWO, Saskatoon, Saskatchewan, Canada aut Psychopharmacology Springer-Verlag 100/4(1990-04-01), 542-547 0033-3158 100:4<542 1990 100 213 https://doi.org/10.1007/BF02244009 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244009 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kokkinidis Larry Department of Psychology, University of Saskatchewan, S7N OWO, Saskatoon, Saskatchewan, Canada aut NATIONALLICENCE 700 1- McCarter Bryon Department of Psychology, University of Saskatchewan, S7N OWO, Saskatoon, Saskatchewan, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/4(1990-04-01), 542-547 0033-3158 100:4<542 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer