caa a22 4500 465739237 CHVBK 20180323111804.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF02244003 doi (NATIONALLICENCE)springer-10.1007/BF02244003 DSP-4-induced depletion of brain norepinephrine produces opposite effects on exploratory behavior 3 and 14 days after treatment [Elektronische Daten] [Craig Berridge, Adrian Dunn] Exploratory behavior of a complex novel environment was examined 3 and 14 days following treatment with the noradrenergic-selective neurotoxin, DSP-4. This toxin significantly decreased norepinephrine concentrations in neocortex and hippocampus but not hypothalamus. DSP-4 significantly increased exploratory behavior in animals tested 3 days after treatment. In contrast, exploratory behavior was decreased in animals tested 14 days after treatment. The effect of DSP-4 at 3 days is similar to treatments that act to inhibit noradrenergic function such as administration of the α1-antagonist, prazosin, or the α2-agonist, clonidine. The effect of DSP-4 at 14 days resembles that observed following treatment with the α1-agonist, phenylephrine, or the α2-antagonist, idazoxan. These data provide additional support for a role of noradrenergic systems in exploratory behavior. The simplest explanation for the time dependent effects of DSP-4 on exploratory behavior is the occurrence of the slow development of a supersensitivity of cerebral systems affected by norepinephrine. Springer-Verlag, 1990 Norepinephrine nationallicence DSP-4 nationallicence Exploratory behavior nationallicence Berridge Craig Department of Neuroscience, University of Florida College of Medicine, 32610, Gainesville, FL, USA aut Dunn Adrian Department of Neuroscience, University of Florida College of Medicine, 32610, Gainesville, FL, USA aut Psychopharmacology Springer-Verlag 100/4(1990-04-01), 504-508 0033-3158 100:4<504 1990 100 213 https://doi.org/10.1007/BF02244003 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244003 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berridge Craig Department of Neuroscience, University of Florida College of Medicine, 32610, Gainesville, FL, USA aut NATIONALLICENCE 700 1- Dunn Adrian Department of Neuroscience, University of Florida College of Medicine, 32610, Gainesville, FL, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/4(1990-04-01), 504-508 0033-3158 100:4<504 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer