caa a22 4500 46573930X CHVBK 20180323111804.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF02244002 doi (NATIONALLICENCE)springer-10.1007/BF02244002 The effects of gepirone on neuroendocrine function and temperature in humans [Elektronische Daten] [I. Anderson, P. Cowen, D. Grahame-Smith] The effects of the selective 5-HT1A receptor agonist gepirone (10 and 20 mg orally) on neuroendocrine function and temperature were assessed using a single-blind cross-over design in 12 healthy male volunteers. Gepirone significantly increased plasma levels of ACTH,β-endorphin, cortisol, prolactin and growth hormone. Following gepirone there was a significant decrease in body temperature and moderate increases in subjective reports of light-headedness, nausea and drowsiness. Our results are consistent with studies in rodents suggesting that 5-HT1A receptor agonists increase ACTH and prolactin secretion and decrease body temperature. Further investigations are needed to determine if the neuroendocrine and temperature effects of gepirone in humans are mediated by 5-HT1A receptors. Springer-Verlag, 1990 5-HT receptors nationallicence Gepirone nationallicence Anterior pituitary hormones nationallicence Temperature nationallicence Anderson I. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Littlemore, Oxford, UK aut Cowen P. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Littlemore, Oxford, UK aut Grahame-Smith D. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Littlemore, Oxford, UK aut Psychopharmacology Springer-Verlag 100/4(1990-04-01), 498-503 0033-3158 100:4<498 1990 100 213 https://doi.org/10.1007/BF02244002 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244002 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Anderson I. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Littlemore, Oxford, UK aut NATIONALLICENCE 700 1- Cowen P. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Littlemore, Oxford, UK aut NATIONALLICENCE 700 1- Grahame-Smith D. MRC Unit of Clinical Pharmacology and University Department of Psychiatry, Littlemore Hospital, OX4 4XN, Littlemore, Oxford, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/4(1990-04-01), 498-503 0033-3158 100:4<498 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer