caa a22 4500 465739326 CHVBK 20180323111804.0 cr unu---uuuuu 170327e19900401xx s 000 0 eng 10.1007/BF02244012 doi (NATIONALLICENCE)springer-10.1007/BF02244012 Antianxiety effect of cannabidiol in the elevated plus-maze [Elektronische Daten] [F. Guimarães, T. Chiaretti, F. Graeff, A. Zuardi] In order to assess the presence of anxiolytic properties in cannabidiol (CBD) the drug was tested in an elevated plus-maze model of anxiety, in rats. Doses of 2.5, 5.0 and 10.0 mg/kg significantly increased the entry ratio (open/total number of entries), an anxiolytic-like effect. CBD at a dose of 20.0 mg/kg was no longer effective. None of the doses of CBD used changed total number of entries, a measure of total exploratory activity. Diazepam (2.0 mg/kg) also caused an anxiolytic-like effect in this model. These results indicate that CBD causes a selective anxiolytic effect in the elevated plusmaze, within a limited range of doses. Springer-Verlag, 1990 Cannabidiol nationallicence Anxiety nationallicence Elevated plus-maze nationallicence Guimarães F. Department of Pharmacology, Campus of the University of São Paulo, BR 14049, Ribeirão Preto, SP, Brazil aut Chiaretti T. Department of Pharmacology, Campus of the University of São Paulo, BR 14049, Ribeirão Preto, SP, Brazil aut Graeff F. Laboratory of Psychobiology, FFCLRP, Campus of the University of São Paulo, BR 14049, Ribeirão Preto, SP, Brazil aut Zuardi A. Department of Neuropsychiatry, FMRP, Campus of the University of São Paulo, BR 14049, Ribeirão Preto, SP, Brazil aut Psychopharmacology Springer-Verlag 100/4(1990-04-01), 558-559 0033-3158 100:4<558 1990 100 213 https://doi.org/10.1007/BF02244012 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244012 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Guimarães F. Department of Pharmacology, Campus of the University of São Paulo, BR 14049, Ribeirão Preto, SP, Brazil aut NATIONALLICENCE 700 1- Chiaretti T. Department of Pharmacology, Campus of the University of São Paulo, BR 14049, Ribeirão Preto, SP, Brazil aut NATIONALLICENCE 700 1- Graeff F. Laboratory of Psychobiology, FFCLRP, Campus of the University of São Paulo, BR 14049, Ribeirão Preto, SP, Brazil aut NATIONALLICENCE 700 1- Zuardi A. Department of Neuropsychiatry, FMRP, Campus of the University of São Paulo, BR 14049, Ribeirão Preto, SP, Brazil aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/4(1990-04-01), 558-559 0033-3158 100:4<558 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer