caa a22 4500 465739334 CHVBK 20180323111804.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02244412 doi (NATIONALLICENCE)springer-10.1007/BF02244412 Effect of diazepam on behaviour and associated changes in ascorbate concentration in rat brain areas: striatum, n. accumbens and hippocampus [Elektronische Daten] [Martyn Boutelle, Lennart Svensson, Marianne Fillenz] The effect of diazepam on spontaneous and tailpinch-induced behaviour was monitored together with the measurement of extracellular ascorbate using constant potential voltammetry with carbon paste electrodes. Diazepam (3 mg/kg) was followed by eating during the 1st hour after administration in non-food-deprived rats and a reduction in the behaviour triggered by a mild tail-pinch 90 min after drug administration. There was no change in ascorbate concentration in parallel with the spontaneous eating; however, the brisk increase in ascorbate concentration in striatum, nucleus accumbens and hippocampus, which accompanies the tail-pinch, was decreased in size and duration after diazepam. This effect was blocked by the central benzodiazepine receptor antagonist Ro15 1788 (5 mg/kg). Springer-Verlag, 1990 Diazepam nationallicence Tail-pinch nationallicence Ascorbate nationallicence Voltammetry nationallicence Eating nationallicence Ro15 1788 nationallicence Rat nationallicence Boutelle Martyn University Laboratory of Physiology, Parks Road, OX1 3PT, Oxford, UK aut Svensson Lennart University Laboratory of Physiology, Parks Road, OX1 3PT, Oxford, UK aut Fillenz Marianne University Laboratory of Physiology, Parks Road, OX1 3PT, Oxford, UK aut Psychopharmacology Springer-Verlag 100/2(1990-02-01), 230-236 0033-3158 100:2<230 1990 100 213 https://doi.org/10.1007/BF02244412 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244412 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boutelle Martyn University Laboratory of Physiology, Parks Road, OX1 3PT, Oxford, UK aut NATIONALLICENCE 700 1- Svensson Lennart University Laboratory of Physiology, Parks Road, OX1 3PT, Oxford, UK aut NATIONALLICENCE 700 1- Fillenz Marianne University Laboratory of Physiology, Parks Road, OX1 3PT, Oxford, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/2(1990-02-01), 230-236 0033-3158 100:2<230 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer