caa a22 4500 465739342 CHVBK 20180323111804.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02244399 doi (NATIONALLICENCE)springer-10.1007/BF02244399 Paternal alcohol exposure: paradoxical effect in mice and rats [Elektronische Daten] [E. Abel, P. Bilitzke] Male mice consumed liquid alcohol diets containing 25%, 10% or 0% ethanol-derived calories (EDC). Animals receiving the 10 and 0% EDC diets were pair fed to those consuming the 25% EDC diet. After 7 or 14 weeks of consumption, males were bred to non-treated females. Offspring were tested for swimming behavior at 75 days of age. Offspring sired by alcohol-consuming males weremore immobile regardless of duration of paternal alcohol consumption or housing conditions (group or isolated). Imipramine (5, 15 mg/kg) reversed this effect such that after drug treatment, alcohol-sired offspring wereless immobile than controls. Propranolol (1, 3 mg/kg) eliminated the group differences. Yohimbine (1, 10 mg/kg) significantly increased immobility in all groups but did not reverse the effects of paternal alcohol consumption. Metergoline (1 mg/kg) increased immobility in all groups but did not reverse the effects of paternal alcohol exposure. When rat offspring of alcohol-consuming fathers were tested, their swimming behavior was opposite to that of mice (i.e., rats wereless immobile). However, as observed in mice, the effect was reversed by imipramine. These results extend the evidence for paternally mediated behavioral mutagenesis. They also indicate that the direction of induced changes are species dependent and that some of these effects, regardless of direction of change, are mediated by neurochemical changes sensitive to imipramine. Springer-Verlag, 1990 Paternal alcohol nationallicence Swimming nationallicence Imipramine nationallicence Propranolol nationallicence Yohimbine nationallicence Metergoline nationallicence Mouse nationallicence Rat nationallicence Abel E. Department of OB/GYN and Fetal Alcohol Research Center, Wayne State University, 48201, Detroit, MI, USA aut Bilitzke P. Department of OB/GYN and Fetal Alcohol Research Center, Wayne State University, 48201, Detroit, MI, USA aut Psychopharmacology Springer-Verlag 100/2(1990-02-01), 159-164 0033-3158 100:2<159 1990 100 213 https://doi.org/10.1007/BF02244399 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244399 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abel E. Department of OB/GYN and Fetal Alcohol Research Center, Wayne State University, 48201, Detroit, MI, USA aut NATIONALLICENCE 700 1- Bilitzke P. Department of OB/GYN and Fetal Alcohol Research Center, Wayne State University, 48201, Detroit, MI, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/2(1990-02-01), 159-164 0033-3158 100:2<159 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer