caa a22 4500 465739350 CHVBK 20180323111804.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02244409 doi (NATIONALLICENCE)springer-10.1007/BF02244409 Effects of NMDA receptor antagonists on passive avoidance learning and retrieval in rats and mice [Elektronische Daten] [Nancy Venable, Peter Kelly] The effects of NMDA antagonists on passive avoidance learning, shock sensitivity and locomotor activity were examined. Pre-training administration of the antagonists 3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) and (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801) in mice and rats resulted in impaired performance in a retention test 24 h later. No such impairment resulted from immediate post-training administration of either compound in either species. In addition neither compound, given only before the retention test, reduced the retention latencies of mice. In rats CPP was similarly ineffective whereas MK-801 reduced retention latencies, but only at a dose which significantly elevated locomotor activity at the time of the retention test. As assessed by vocalization threshold in mice and by the proportion of animals vocalizing in response to the passive avoidance training shock, neither compound produced analgesia. The vocalization threshold was, in fact, slightly reduced by both compounds. MK-801, but not CPP, stimulated locomotor activity in mice. These results indicate that in the passive avoidance task activation of NMDA receptors is involved in memory formation, but is not critical for the maintenance of memory or its retrieval. Springer-Verlag, 1990 NMDA receptor antagonists nationallicence Passive avoidance learning nationallicence Locomotor activity nationallicence Vocalization threshold nationallicence Rodents nationallicence Venable Nancy Preclinical Research, Sandoz, Ltd., CH-4002, Basel, Switzerland aut Kelly Peter Preclinical Research, Sandoz, Ltd., CH-4002, Basel, Switzerland aut Psychopharmacology Springer-Verlag 100/2(1990-02-01), 215-221 0033-3158 100:2<215 1990 100 213 https://doi.org/10.1007/BF02244409 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244409 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Venable Nancy Preclinical Research, Sandoz, Ltd., CH-4002, Basel, Switzerland aut NATIONALLICENCE 700 1- Kelly Peter Preclinical Research, Sandoz, Ltd., CH-4002, Basel, Switzerland aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/2(1990-02-01), 215-221 0033-3158 100:2<215 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer