caa a22 4500 465739415 CHVBK 20180323111804.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02244414 doi (NATIONALLICENCE)springer-10.1007/BF02244414 Scopolamine effects on memory, language, visuospatial praxis and psychomotor speed [Elektronische Daten] [Charles Flicker, Michael Serby, Steven Ferris] Scopolamine hydrobromide was administered by subcutaneous injection to 30 young subjects in a dose of 0.22 mg/70 kg, 0.43 mg/70 kg, or 0.65 mg/70 kg. Treatment effects were compared to placebo on an extensive cognitive assessment battery. Almost all tests in the battery had been previously administered to Alzheimer's disease patients and nondemented elderly subjects. Scopolamine produced deficits on tests of verbal recall, visuospatial recall, visual recognition memory, visuospatial praxis, visuoperceptual function, and psychomotor speed. Immediate memory, language function, object sorting, and frequency of intrusion errors were unaffected. The low dose of scopolamine produced some peripheral anticholinergic signs but did not affect the cognitive measures. The results support the conclusion reached in previous studies that the cognitive profile of scopolamine-injected young subjects is more similar to that of the nondemented elderly than to that of Alzheimer's disease patients. Springer-Verlag, 1990 Scopolamine nationallicence Acetylcholine nationallicence Aging nationallicence Alzheimer's disease nationallicence Memory nationallicence Cognition nationallicence Flicker Charles Department of Psychiatry (HN 314), New York University Medical Center, 10016, New York, NY, USA aut Serby Michael Department of Psychiatry (HN 314), New York University Medical Center, 10016, New York, NY, USA aut Ferris Steven Department of Psychiatry (HN 314), New York University Medical Center, 10016, New York, NY, USA aut Psychopharmacology Springer-Verlag 100/2(1990-02-01), 243-250 0033-3158 100:2<243 1990 100 213 https://doi.org/10.1007/BF02244414 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244414 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Flicker Charles Department of Psychiatry (HN 314), New York University Medical Center, 10016, New York, NY, USA aut NATIONALLICENCE 700 1- Serby Michael Department of Psychiatry (HN 314), New York University Medical Center, 10016, New York, NY, USA aut NATIONALLICENCE 700 1- Ferris Steven Department of Psychiatry (HN 314), New York University Medical Center, 10016, New York, NY, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/2(1990-02-01), 243-250 0033-3158 100:2<243 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer