caa a22 4500 465739431 CHVBK 20180323111804.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02244408 doi (NATIONALLICENCE)springer-10.1007/BF02244408 Effects of N-methyl- d -aspartate antagonism on spatial learning in mice [Elektronische Daten] [Margaret Upchurch, Jeanne Wehner] C57BL/6Ibg mice were treated with the N-methyl-d-aspartate (NMDA) receptor antagonist 3-(2-carboxypiperazin-4-yl) propyl-1-phosphonic acid (CPP) and tested for selective deficits in spatial learning ability in the Morris water task. Two types of training protocols were used during the initial exposure to the training environment. In protocol 1, animals were given four massed trials before being returned to their home cages. In protocol 2, animals were returned to their home cages after each of the first four trials. Following the initial four trials, both sets of animals were given massed trials in blocks of four. CPP had minor effects on nonspatial learning, with greater impairment seen in animals trained according to protocol 1 than in animals trained according to protocol 2. The drug increased latency to find the platform in the spatial learning form of the task, with no effect of training protocol on latency. When spatial learning ability was measured in terms of the search behavior exhibited by the animals after the platform was removed from the pool, animals trained according to protocol 1 showed a severe CPP-induced impairment in search accuracy. Animals trained according to protocol 2 showed no effect of drug treatment. The results suggest that CPP does not have a reliable effect on place learning and that factors other than the type of learning being tested may contribute to performance deficits following CPP treatment. Springer-Verlag, 1990 Spatial learning nationallicence NMDA nationallicence CPP nationallicence C57BL/6 nationallicence Training protocol nationallicence Upchurch Margaret Institute for Behavioral Genetics, University of Colorado, Campus Box 447, 80309, Boulder, CO, USA aut Wehner Jeanne Institute for Behavioral Genetics, University of Colorado, Campus Box 447, 80309, Boulder, CO, USA aut Psychopharmacology Springer-Verlag 100/2(1990-02-01), 209-214 0033-3158 100:2<209 1990 100 213 https://doi.org/10.1007/BF02244408 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244408 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Upchurch Margaret Institute for Behavioral Genetics, University of Colorado, Campus Box 447, 80309, Boulder, CO, USA aut NATIONALLICENCE 700 1- Wehner Jeanne Institute for Behavioral Genetics, University of Colorado, Campus Box 447, 80309, Boulder, CO, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/2(1990-02-01), 209-214 0033-3158 100:2<209 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer