caa a22 4500 46573944X CHVBK 20180323111804.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02244405 doi (NATIONALLICENCE)springer-10.1007/BF02244405 Linseman M. Biobehavioral Studies Department, Addiction Research Foundation, 33 Russell Street, M5S 2S1, Toronto, Canada aut Effects of dopaminergic agents on alcohol consumption by rats in a limited access paradigm [Elektronische Daten] [M. Linseman] The effects of several dopaminergic drugs on alcohol consumption were studied in free-feeding rats using a limited access paradigm. Ascending doses of amphetamine (0.1, 0.3 and 1.0 mg/kg), haloperidol (0.1, 0.3 and 1.0 mg/kg), SKF 38 393 (a D1 receptor agonist − 0.3, 1.0 and 3.0 mg/kg), quinpirole (LY 171 555, a D2 receptor agonist − 0.03, 0.1 and 0.3 mg/kg), SCH 23 390 (a D1 receptor blocker, 0.003, 0.01, 0.03 and 0.1 mg/kg) and spiperone (a D2 receptor blocker, 0.003, 0.01, 0.03 and 0.1 mg/kg) were administered IP to rats approximately 30 min prior to their 1-h per day access to alcohol. Each dose was administered for 5 successive days, and the effects of the drugs were compared to those of respective saline or 0.4% lactic acid solution controls. Although there was an overall significant dose effect of amphetamine on alcohol consumption, no single dose altered alcohol consumption significantly from baseline. SKF 38 393 specifically decreased alcohol consumption at the highest dose of 3 mg/kg. Quinpirole significantly increased water consumption at the highest dose but had no effect on alcohol consumption. The antagonist haloperidol decreased alcohol consumption but only at doses that also reduced water consumption. The specific antagonists SCH 23 390 and spiperone decreased water consumption at the highest doses tested without modifying alcohol consumption. Taken together, these data suggest that dopamine does not play as critical a role in mediating the reinforcing effects of alcohol (insofar as they are reflected by alcohol consumption) as it does in relation to other psychoactive drugs, particularly the psychomotor stimulants. Springer-Verlag, 1990 Alcohol nationallicence Ethanol nationallicence Drinking nationallicence Self-administration nationallicence Dopamine nationallicence Amphetamine nationallicence Haloperidol nationallicence SKF 38 393 nationallicence Quinpirole nationallicence SCH 23 390 nationallicence Spiperone nationallicence Psychopharmacology Springer-Verlag 100/2(1990-02-01), 195-200 0033-3158 100:2<195 1990 100 213 https://doi.org/10.1007/BF02244405 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244405 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Linseman M. Biobehavioral Studies Department, Addiction Research Foundation, 33 Russell Street, M5S 2S1, Toronto, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/2(1990-02-01), 195-200 0033-3158 100:2<195 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer