caa a22 4500 465739458 CHVBK 20180323111804.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02244403 doi (NATIONALLICENCE)springer-10.1007/BF02244403 The anorectic effect of SK&F 38393, a selective dopamine D1 receptor agonist: a microstructural analysis of feeding and related behaviour [Elektronische Daten] [S. Cooper, J. Francis, I. Rusk] An observational study was undertaken to provide a microstructural analysis of the effects of the selective dopamine D1 receptor agonist, SK&F 38393, on feeding and associated behaviours in the rat. Adult, male non-deprived rats were adapted to eating a meal of sweetened mash in a 30-min period. SK&F 38393 (3.0 and 10 mg/kg, SC) significantly reduced food consumption). It also reduced the frequency of feeding bouts and the local rate of eating, while there was an increase, at 10 mg/kg, in the mean duration of individual feeding episodes. The D1 receptor agonist also reduced the total duration of locomotor activity, but did not affect the total duration of rearing, grooming, sniffing, oral behaviours (other than feeding), or resting. The frequency of bouts of locomotion, rearing, grooming, and sniffing were reduced by SK&F 38393. Consideration of the time-courses for the several responses suggested that SK&F 38393 did not materially affect the form and sequence of behavioural responses in the test, although some changes occurred. Springer-Verlag, 1990 Dopamine D1 receptor nationallicence Feeding nationallicence Microstructural analysis nationallicence Grooming nationallicence SK&F 38393 nationallicence Rats nationallicence Cooper S. School of Psychology, University of Birmingham, B15 2TT, Birmingham, UK aut Francis J. School of Psychology, University of Birmingham, B15 2TT, Birmingham, UK aut Rusk I. School of Psychology, University of Birmingham, B15 2TT, Birmingham, UK aut Psychopharmacology Springer-Verlag 100/2(1990-02-01), 182-187 0033-3158 100:2<182 1990 100 213 https://doi.org/10.1007/BF02244403 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244403 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cooper S. School of Psychology, University of Birmingham, B15 2TT, Birmingham, UK aut NATIONALLICENCE 700 1- Francis J. School of Psychology, University of Birmingham, B15 2TT, Birmingham, UK aut NATIONALLICENCE 700 1- Rusk I. School of Psychology, University of Birmingham, B15 2TT, Birmingham, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/2(1990-02-01), 182-187 0033-3158 100:2<182 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer