caa a22 4500 465739466 CHVBK 20180323111804.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02244410 doi (NATIONALLICENCE)springer-10.1007/BF02244410 Sleep laboratory investigations on hypnotic properties of melatonin [Elektronische Daten] [F. Waldhauser, B. Saletu, I. Trinchard-Lugan] Melatonin (MLT), a pineal hormone, has some sedative and hypnotic properties. To explore this effect further 20 young, healthy volunteers exposed to artificial insomnia participated in a double-blind, placebo controlled, parallel group design study. They slept in a sleep laboratory for several consecutive nights and were polygraphically monitored and subjected to a battery of psychometric tests and standardized self-report questionnaires each morning. One night all subjects received only placebo (21:00 hours) and on a second night half of them were subjected to placebo and half to MLT. On the later night blood MLT levels were measured. Polygraphic recordings revealed that MLT at bedtime decreased the time the subjects were awake before sleep onset (P<0.025), sleep latency (P<0.05), and the number of awakenings during the total sleep period (P<0.025), and increased sleep efficiency (P<0.05). In addition, it decreased sleep stage 1 (P<0.05) and increased sleep stage 2 (P<0.025). On the morning following the treatment most objective and subjective measures for awakening quality showed a trend towards improvement after MLT. One hour after its oral administration, serum MLT rose to a high pharmacological level (25817 pg/ml; median), but individual peak serum MLT levels varied by a factor of 300. From the data collected it is concluded that a single pharmacological dose of MLT exerts a hypnotic effect by accelerating sleep initiation, improving sleep maintenance and altering sleep architecture in a similar manner to anxiolytic sedatives; objective and subjective measures for awakening qualitiy indicate good tolerance of one dose of MLT without hangover problems on the following morning. Oral administration of crystalline MLT, however, results in high interindividual differences in absorption. Springer-Verlag, 1990 Melatonin nationallicence Sleep nationallicence Behavior nationallicence Performance nationallicence Sleep laboratory nationallicence Waldhauser F. Department of Pediatrics, University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria aut Saletu B. Department of Psychiatry, University of Vienna, Vienna, Austria aut Trinchard-Lugan I. Department of Pediatrics, University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria aut Psychopharmacology Springer-Verlag 100/2(1990-02-01), 222-226 0033-3158 100:2<222 1990 100 213 https://doi.org/10.1007/BF02244410 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244410 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Waldhauser F. Department of Pediatrics, University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria aut NATIONALLICENCE 700 1- Saletu B. Department of Psychiatry, University of Vienna, Vienna, Austria aut NATIONALLICENCE 700 1- Trinchard-Lugan I. Department of Pediatrics, University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/2(1990-02-01), 222-226 0033-3158 100:2<222 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer