caa a22 4500 465739474 CHVBK 20180323111804.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02244397 doi (NATIONALLICENCE)springer-10.1007/BF02244397 A taste aversion model of drug discrimination learning: training drug and condition influence rate of learning, sensitivity and drug specificity [Elektronische Daten] [Thomas Jaeger, Ronald Mucha] A model of drug discrimination based on a lithium chloride (LiCl) flavour aversion was described and examined. Mildly thirsty rats were presented daily with 4 ml of a distinctly flavoured solution which was followed on 50% of the days by an IP injection of LiCl. Prior to the flavour presentation, the rats were injection SC with saline or a training drug (0.04 mg/kg fentanyl or 20 mg/kg pentobarbital) to signal whether LiCl would follow. Almost all rats eventually exhibited stable behaviour that involved drinking most or all of the fluid when it was not to be followed by LiCl and little or no drinking when it was. Such discrimination occurred regardless of whether drug predicted LiCl (learned-discomfort) or predicted no LiCl (learned-safety). However, with fentanyl there were clear differences between rats trained with drug under learned-safety and under learned-discomfort conditions for 1) the rate of acquisition of stable performance as a function of LiCl dose, 2) generalization of the training dose to a test dose that was lower, and 3) elicitation of fentanyl responses by pentobarbital. These findings, together with indications that such effects did not always occur with pentobarbital as the training drug, were discussed from theoretical and practical perspectives. Springer-Verlag, 1990 Taste aversion nationallicence Drug discrimination nationallicence Fentanyl nationallicence Pentobarbital nationallicence Drinking nationallicence Opiates nationallicence Lithium chloride nationallicence Subjective drug effects nationallicence Jaeger Thomas Department of Pharmacology, University of Toronto and Addiction Research Foundation of Ontario, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut Mucha Ronald Department of Pharmacology, University of Toronto and Addiction Research Foundation of Ontario, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut Psychopharmacology Springer-Verlag 100/2(1990-02-01), 145-150 0033-3158 100:2<145 1990 100 213 https://doi.org/10.1007/BF02244397 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244397 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jaeger Thomas Department of Pharmacology, University of Toronto and Addiction Research Foundation of Ontario, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Mucha Ronald Department of Pharmacology, University of Toronto and Addiction Research Foundation of Ontario, 33 Russell Street, M5S 2S1, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/2(1990-02-01), 145-150 0033-3158 100:2<145 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer