caa a22 4500 465739482 CHVBK 20180323111804.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02244396 doi (NATIONALLICENCE)springer-10.1007/BF02244396 Possible involvement of differing classes of dopamine D-2 receptors in yawning and stereotypy in rats [Elektronische Daten] [Katsushi Yamada, Mariko Nagashima, Hiroshi Kimura, Shin-ichiro Matsumoto, Tatsuo Furukawa] The present experiments were performed to investigate differences in the properties of the dopamine D-2 receptors related to yawning and stereotypy. Subcutaneous injection of talipexole (B-HT 920) (10-250 µg/kg) or SND 919 ((S)-2-amino-4,5,6,7-tetrahydro-6-propylamino-benzothiazole) (25-500 µg/kg) evoked yawning behavior with bell-shaped responses. However, SK&F 38393 (1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol) (0.5-10 mg/kg SC) did not elicit yawning and decreased yawning responses to low doses of talipexole (25 µg/kg SC) or SND 919 (100 µg/kg SC). These low but effective doses for inducing yawning of talipexole or SND 919 in combination with SK&F 38393 (0.5-10 mg/kg SC) did not elicit stereotypy. In contrast, yawning behavior was not produced after very high doses of talipexole (500 µg/kg SC) or SND 919 (1000 µg/kg SC) given alone or in combination with SK&F 38393 (0.5-10 mg/kg SC). These extremely high doses of talipexole or SND 919 evoked slight stereotypy, which was enhanced by the combined treatment with SK&F 38393. The present results suggest that the dopamine D-2 receptors related to yawning are more sensitive to dopamine receptor agonists than those related to stereotypy, and that concurrent stimulation of postsynaptic dopamine D-1 receptors with D-2 receptors reduces the incidence of yawning but enhances that of stereotypy. Springer-Verlag, 1990 Yawning behavior nationallicence Stereotypy nationallicence Dopamine D-2 receptor agonists nationallicence Dopamine D-1 receptor agonists nationallicence Talipexole nationallicence B-HT 920 nationallicence SND 919 nationallicence SK&F 38393 nationallicence Rats nationallicence Yamada Katsushi Department of Pharmacology, School of Medicine, Fukuoka University, 814-01, Fukuoka, Japan aut Nagashima Mariko Research Laboratory of Biodynamics, School of Medicine, Fukuoka University, 814-01, Fukuoka, Japan aut Kimura Hiroshi Department of Pharmacology, School of Medicine, Fukuoka University, 814-01, Fukuoka, Japan aut Matsumoto Shin-ichiro Department of Pharmacology, School of Medicine, Fukuoka University, 814-01, Fukuoka, Japan aut Furukawa Tatsuo Department of Pharmacology, School of Medicine, Fukuoka University, 814-01, Fukuoka, Japan aut Psychopharmacology Springer-Verlag 100/2(1990-02-01), 141-144 0033-3158 100:2<141 1990 100 213 https://doi.org/10.1007/BF02244396 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244396 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamada Katsushi Department of Pharmacology, School of Medicine, Fukuoka University, 814-01, Fukuoka, Japan aut NATIONALLICENCE 700 1- Nagashima Mariko Research Laboratory of Biodynamics, School of Medicine, Fukuoka University, 814-01, Fukuoka, Japan aut NATIONALLICENCE 700 1- Kimura Hiroshi Department of Pharmacology, School of Medicine, Fukuoka University, 814-01, Fukuoka, Japan aut NATIONALLICENCE 700 1- Matsumoto Shin-ichiro Department of Pharmacology, School of Medicine, Fukuoka University, 814-01, Fukuoka, Japan aut NATIONALLICENCE 700 1- Furukawa Tatsuo Department of Pharmacology, School of Medicine, Fukuoka University, 814-01, Fukuoka, Japan aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/2(1990-02-01), 141-144 0033-3158 100:2<141 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer