caa a22 4500 465739512 CHVBK 20180323111804.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02244407 doi (NATIONALLICENCE)springer-10.1007/BF02244407 Ritanserin, a 5-HT2 receptor antagonist, does not modify ECT-induced prolactin release [Elektronische Daten] [Y. Papakostas, M. Markianos, G. Papadimitriou, C. Stefanis] The effect of pretreatment with ritanserin, a potent and selective serotonin-S2 (5-HT2) receptor antagonist, on the prolactin (PRL) response to electroconvulsive therapy (ECT) was studied in seven female patients suffering from major depressive disorder. They were given either ECT alone, or ECT after 10 or 20 mg ritanserin PO, and PRL was estimated in blood samples taken at times −5, 0, +5, +15, +30 and +60 min. The PRL responses after drug administration were not different from the responses after ECT alone. We conclude that, if serotonergic mechanisms are involved in the ECT-induced PRL increase, this neuroendocrine response seems to be rather a 5-HT1 than 5-HT2 receptor mediated event. Springer-Verlag, 1990 ECT nationallicence Prolactin nationallicence Ritanserin nationallicence Serotonin receptors nationallicence Antagonism nationallicence Papakostas Y. Psychiatric Clinic, Eginition Hospital, Athens University Medical School, Vas. Sophias 74, 11 528, Athens, Greece aut Markianos M. Psychiatric Clinic, Eginition Hospital, Athens University Medical School, Vas. Sophias 74, 11 528, Athens, Greece aut Papadimitriou G. Psychiatric Clinic, Eginition Hospital, Athens University Medical School, Vas. Sophias 74, 11 528, Athens, Greece aut Stefanis C. Psychiatric Clinic, Eginition Hospital, Athens University Medical School, Vas. Sophias 74, 11 528, Athens, Greece aut Psychopharmacology Springer-Verlag 100/2(1990-02-01), 206-208 0033-3158 100:2<206 1990 100 213 https://doi.org/10.1007/BF02244407 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244407 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Papakostas Y. Psychiatric Clinic, Eginition Hospital, Athens University Medical School, Vas. Sophias 74, 11 528, Athens, Greece aut NATIONALLICENCE 700 1- Markianos M. Psychiatric Clinic, Eginition Hospital, Athens University Medical School, Vas. Sophias 74, 11 528, Athens, Greece aut NATIONALLICENCE 700 1- Papadimitriou G. Psychiatric Clinic, Eginition Hospital, Athens University Medical School, Vas. Sophias 74, 11 528, Athens, Greece aut NATIONALLICENCE 700 1- Stefanis C. Psychiatric Clinic, Eginition Hospital, Athens University Medical School, Vas. Sophias 74, 11 528, Athens, Greece aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/2(1990-02-01), 206-208 0033-3158 100:2<206 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer