caa a22 4500 465739520 CHVBK 20180323111804.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02244400 doi (NATIONALLICENCE)springer-10.1007/BF02244400 Increased serotonin 5-HT2 receptor binding on blood platelets of suicidal men [Elektronische Daten] [Anat Biegon, Alexander Grinspoon, Batia Blumenfeld, Avraham Bleich, Alan Apter, Roberto Mester] In search of a physiological marker of depression and suicidal behavior, serotonin receptors of the 5-HT2 type were studied on platelet membranes from 19 control and 22 suicidal subjects. All were young, drug — and medication free men (18-21-years-old). 5-HT2 receptor binding was assayed using tritiated ketanserine at two concentrations. Receptor binding in the suicidal subjects was significantly higher than controls at both concentrations, the mean difference being around 50%. A similar difference between patients with major depressive disorder and matched controls has been observed previously. These findings support the use of 5-HT2 receptors on platelets as a research and diagnostic tool in depression and suicide. Springer-Verlag, 1990 Serotonin nationallicence Suicide nationallicence 5-HT2 receptors nationallicence Platelets nationallicence Biegon Anat The Weizmann Institute of Science, Rehovot, Israel aut Grinspoon Alexander Mental Health Department, Israel Defense Force, Israel aut Blumenfeld Batia Ness Ziona Mental Health Center, Ness Ziona, Israel aut Bleich Avraham Mental Health Department, Israel Defense Force, Israel aut Apter Alan Mental Health Department, IDF and Sackler School of Medicine, Tel Aviv University, Israel aut Mester Roberto Ness Ziona Mental Health Center, Ness Ziona, Israel aut Psychopharmacology Springer-Verlag 100/2(1990-02-01), 165-167 0033-3158 100:2<165 1990 100 213 https://doi.org/10.1007/BF02244400 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244400 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Biegon Anat The Weizmann Institute of Science, Rehovot, Israel aut NATIONALLICENCE 700 1- Grinspoon Alexander Mental Health Department, Israel Defense Force, Israel aut NATIONALLICENCE 700 1- Blumenfeld Batia Ness Ziona Mental Health Center, Ness Ziona, Israel aut NATIONALLICENCE 700 1- Bleich Avraham Mental Health Department, Israel Defense Force, Israel aut NATIONALLICENCE 700 1- Apter Alan Mental Health Department, IDF and Sackler School of Medicine, Tel Aviv University, Israel aut NATIONALLICENCE 700 1- Mester Roberto Ness Ziona Mental Health Center, Ness Ziona, Israel aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/2(1990-02-01), 165-167 0033-3158 100:2<165 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer