caa a22 4500 465739539 CHVBK 20180323111804.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02244418 doi (NATIONALLICENCE)springer-10.1007/BF02244418 Bromocriptine induces climbing behaviour: possible D-1 or D-2 dopamine receptor involvement [Elektronische Daten] [Mohammad-Reza Zarrindast, Katayoun Shahed-Dirin] The ability of bromocriptine (BRC), a dopamine D-2 receptor agonist, to induce climbing behaviour was studied in mice. BRC (2-32 mg/kg IP) evoked climbing behaviour. The maximum effect was obtained with 8 mg/kg, while higher doses of BRC (16 and 32 mg/kg) were less effective. Climbing began about 2 h after injection and was most marked 5 h after bromocriptine administration. Pretreatment of animals with the dopamine antagonist pimozide (0.5 mg/kg IP) decreased BRC-induced climbing. Sulpiride (0.25-1.25 mg/kg IP), a potent D-2 antagonist and/or SCH 23390 (0.025 and 0.05 mg/kg SC), a D-1 receptor antagonist, also decreased the response. Furthermore, the climbing behaviour induced by BRC was abolished by pretreatment with reserpine plus alpha-methyl-p-tyrosine (AMPT). Concomitant administration of apomorphine (APO) and BRC potentiated the effect of APO on climbing. Concomitant injection of BRC and SKF 38393 (SKF, D-1 agonist) reduced the effect of SKF on climbing, while administration of BRC 4 h before SKF potentiated the effect of both drugs. It is suggested that BRC induces climbing through D-1 and/or D-2 dopamine receptors. Springer-Verlag, 1990 D-1 and D-2 receptors nationallicence Apomorphine nationallicence Bromocriptine nationallicence Climbing nationallicence Mice nationallicence Zarrindast Mohammad-Reza Department of Pharmacology, Medical Faculty, University of Tehran, Tehran, Iran aut Shahed-Dirin Katayoun Department of Pharmacology, Medical Faculty, University of Tehran, Tehran, Iran aut Psychopharmacology Springer-Verlag 100/2(1990-02-01), 275-280 0033-3158 100:2<275 1990 100 213 https://doi.org/10.1007/BF02244418 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244418 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zarrindast Mohammad-Reza Department of Pharmacology, Medical Faculty, University of Tehran, Tehran, Iran aut NATIONALLICENCE 700 1- Shahed-Dirin Katayoun Department of Pharmacology, Medical Faculty, University of Tehran, Tehran, Iran aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/2(1990-02-01), 275-280 0033-3158 100:2<275 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer