caa a22 4500 465739547 CHVBK 20180323111805.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02244413 doi (NATIONALLICENCE)springer-10.1007/BF02244413 Changes in seizure threshold and aggression during chronic treatment with three anticonvulsants and on drug withdrawal [Elektronische Daten] [Sandra File, Lucy Wilks] Sodium phenobarbitone (20 and 70 mg/kg) had a significant anticonvulsant action against pentylenetetrazole-induced seizures, which persisted for 21 days of treatment. On drug withdrawal there was a significant decrease in seizure threshold below control level 24-48 h after the last dose of 70 mg/kg. Phenytoin (40 mg/kg) had a significant anticonvulsant action after 7 days of treatment and this persisted for 21 days of treatment. On drug withdrawal there was a significant decrease in seizure threshold 48 h after the last dose. Lorazepam (0.1 mg/kg) had a significant anticonvulsant action, but the group tested after 21 days of treatment did not differ from the controls, indicating that tolerance had developed to this effect; on drug withdrawal there was a decrease in seizure threshold from 24 to 72 h. The only drug to increase aggressive behaviour was sodium phenobarbitone (70 mg/kg); this reached significance after 14 and 21 days of treatment and occurred 8 h after drug administration; 0.5 h after drug administration phenobarbitone (70 mg/kg) abolished aggressive behaviour. After 7 days of treatment phenobarbitone (70 mg/kg) increased social behaviour 0.5 h after administration and this was still increased after 21 days of treatment. On drug withdrawal, there were no changes in aggressive behaviour, but there were significant decreases in social behaviour 24 and 48 h after phenobarbitone (70 mg/kg) withdrawal and 24, 48 and 72 h after lorazepam (0.1 mg/kg) withdrawal. Springer-Verlag, 1990 Barbiturate nationallicence Diphenylhydantoin nationallicence Benzodiazepine nationallicence Anticonvulsant nationallicence Aggression nationallicence Social behaviour nationallicence Tolerance nationallicence Withdrawal nationallicence File Sandra Psychopharmacology Research Unit, UMDS Division of Pharmacology, University of London, Guy's Hospital, SE1 9RT, London, UK aut Wilks Lucy Psychopharmacology Research Unit, UMDS Division of Pharmacology, University of London, Guy's Hospital, SE1 9RT, London, UK aut Psychopharmacology Springer-Verlag 100/2(1990-02-01), 237-242 0033-3158 100:2<237 1990 100 213 https://doi.org/10.1007/BF02244413 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244413 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- File Sandra Psychopharmacology Research Unit, UMDS Division of Pharmacology, University of London, Guy's Hospital, SE1 9RT, London, UK aut NATIONALLICENCE 700 1- Wilks Lucy Psychopharmacology Research Unit, UMDS Division of Pharmacology, University of London, Guy's Hospital, SE1 9RT, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/2(1990-02-01), 237-242 0033-3158 100:2<237 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer