caa a22 4500 465739555 CHVBK 20180323111805.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF02244419 doi (NATIONALLICENCE)springer-10.1007/BF02244419 File Sandra Psychopharmacology Research Unit, Division of Pharmacology, UMDS Guy's Hospital, SE1 9RT, London, UK aut One-trial tolerance to the anxiolytic effects of chlordiazepoxide in the plus-maze [Elektronische Daten] [Sandra File] Chlordiazepoxide (CDP 7.5 mg/kg) had a significant anxiolytic effect in rats tested on the plus-maze for the first time. On a second trial the control scores did not change, but those of the CDP group did and they no longer differed from controls. Rats previously tested undrugged or after flumazenil (4 mg/kg) also failed to show an anxiolytic response to CDP. Thus this phenomenon of one-trial tolerance depended on prior experience with the plus-maze. It also depended on CDP acting at the benzodiazepine receptors on trial 2, since the joint administration of CDP and flumazenil on trial 2 reversed the phenomenon. Springer-Verlag, 1990 Learned tolerance nationallicence Anxiety nationallicence Benzodiazepines nationallicence Psychopharmacology Springer-Verlag 100/2(1990-02-01), 281-282 0033-3158 100:2<281 1990 100 213 https://doi.org/10.1007/BF02244419 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244419 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- File Sandra Psychopharmacology Research Unit, Division of Pharmacology, UMDS Guy's Hospital, SE1 9RT, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 100/2(1990-02-01), 281-282 0033-3158 100:2<281 1990 100 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer