caa a22 4500 465739652 CHVBK 20180323111805.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF02368419 doi (NATIONALLICENCE)springer-10.1007/BF02368419 A theoretical description of arterial pressure-flow relationships with verification in the isolated hindlimb of the dog [Elektronische Daten] [Alan Jackman, Jerry Green] We developed and tested a new two-compartment serial model of the arterial vasculature which unifies the capacitance (downstream arterial compliance) and waterfall (constant downstream pressure load) theories of blood flow through the arteries. In this model, blood drains from an upstream compliance through a resistance into a downstream compliance which empties into the veins through a downstream resistance which terminates in a constant pressure load. Using transient arterial pressure data obtained from an isolated canine hindlimb preparation, we tested this model, using a stop-flow technique. Numerical parameter estimation techniques were used to estimate the physiologic parameters of the model. The downstream compliance was found to be more than ten times larger than the upstream compliance and the constant pressure load was significantly above venous pressures but decreased in response to vasodilation. Our results support the applicability of both the capacitance and waterfall theories. Pergamon Press plc, 1990 Cardiovascular nationallicence Arteries nationallicence Veins nationallicence Pressure-flow relationships nationallicence Waterfall nationallicence Jackman Alan Department of Chemical Engineering, University of California, 95616, Davis, CA aut Green Jerry Department of Human Physiology, University of California, 95616, Davis, CA aut Annals of Biomedical Engineering Kluwer Academic Publishers 18/1(1990-01-01), 89-101 0090-6964 18:1<89 1990 18 10439 https://doi.org/10.1007/BF02368419 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02368419 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jackman Alan Department of Chemical Engineering, University of California, 95616, Davis, CA aut NATIONALLICENCE 700 1- Green Jerry Department of Human Physiology, University of California, 95616, Davis, CA aut NATIONALLICENCE 773 0- Annals of Biomedical Engineering Kluwer Academic Publishers 18/1(1990-01-01), 89-101 0090-6964 18:1<89 1990 18 10439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer